| Gene Information | |
|---|---|
| Gene Name | P3H3 |
| Organism | Homo sapiens (Human) |
| Gene Length | 736 |
| Protein Names | Prolyl 3-hydroxylase 3 (EC 1.14.11.7) (Leprecan-like protein 2) (Protein B) |
| Target Name | prolyl 3-hydroxylase 3 |
| Target Type | NA |
| Gene Age | 454 ( ENSG00000110811 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | Q8IVL6 |
| Gene Card | P3H3 |
| Uniprot ID | Q8IVL6 |
| Pfam | PF13640 |
| In ASD | no |
| Allosteric Prediction | no (-0.812980227) |
| Ortholog in Animals | Alpaca_ P3H3 ( ortholog_one2one ) Dog_ P3H3 ( ortholog_one2one ) GuineaPig_ P3H3 ( ortholog_one2one ) Macaque_ P3H3 ( ortholog_one2one ) Mouse_ P3h3 ( ortholog_one2one ) Pig_ P3H3 ( ortholog_one2one ) Rat_ P3h3 ( ortholog_one2one ) Rabbit_ P3H3 ( ortholog_one2one ) |
| Ohnologs | P3H2, P3H1 |
| Paralogs | P3H1, P3H2 |
| Tissue | NA |
| Tissue Specificity | Detected in fetal cartilage (at protein level) (PubMed:28115524). Weak expression in heart, lung, ovary and skeletal muscle (PubMed:8723724). {ECO:0000269|PubMed:28115524, ECO:0000269|PubMed:8723724}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | rs10744716 rs35359746 rs1047771 rs1129649 rs3213431 |
| Subcellular location [CC] | Endoplasmic reticulum {ECO:0000255|PROSITE-ProRule:PRU10138}. |
| Mouse PG classification | NA |
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