| Gene Information | |
|---|---|
| Gene Name | HPR |
| Organism | Homo sapiens (Human) |
| Gene Length | 348 |
| Protein Names | Haptoglobin-related protein |
| Target Name | haptoglobin-related protein |
| Target Type | NA |
| Gene Age | 382 ( ENSG00000261701 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | P00739 |
| Gene Card | HPR |
| Uniprot ID | P00739 |
| Pfam | PF00089 |
| In ASD | no |
| Allosteric Prediction | yes (0.417842004) |
| Ortholog in Animals | Alpaca_ HPR ( ortholog_one2one ) Dog_ DHODH ( ortholog_one2many ) Mouse_ Hp ( ortholog_one2many ) Rat_ Hp ( ortholog_one2many ) |
| Ohnologs | NA |
| Paralogs | HGFAC, F7, C1R, KLK10, F9, F12, F10, CFI, CFD, PRSS55, PRSS51, C1S, C1RL, KLKB1, F11, HP |
| Tissue | liver, heart |
| Tissue Specificity | In adult liver the amount of HPR mRNA is at the lower limit of detection, therefore the extent of its expression is at most less than 1000-fold that of the HP1F gene. No HPR mRNA can be detected in fetal liver. Expressed in Hep-G2 and leukemia MOLT-4 cell lines. {ECO:0000269|PubMed:8945641}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | rs11642506 rs152832 rs152833 rs1049933 rs2021171 rs1065360 rs12646 |
| Subcellular location [CC] | Secreted {ECO:0000269|PubMed:16778136}. Note=Secreted into blood plasma and associated with subtypes of high density lipoproteins (HDL). {ECO:0000269|PubMed:16778136}. |
| Mouse PG classification | NA |
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