| Gene Information | |
|---|---|
| Gene Name | DAPK1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 1430 |
| Protein Names | Death-associated protein kinase 1 (DAP kinase 1) (EC 2.7.11.1) |
| Target Name | death-associated protein kinase 1 |
| Target Type | NA |
| Gene Age | 886 ( ENSG00000196730 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | P53355 |
| Gene Card | DAPK1 |
| Uniprot ID | P53355 |
| Pfam | PF00023; PF12796; PF13637; PF00531; PF00069 |
| In ASD | no |
| Allosteric Prediction | yes (0.298572192) |
| Ortholog in Animals | Alpaca_ DAPK1 ( ortholog_one2one ) Dog_ DAPK1 ( ortholog_one2one ) GuineaPig_ DAPK1 ( ortholog_one2one ) Macaque_ DAPK1 ( ortholog_one2one ) Mouse_ Dapk1 ( ortholog_one2one ) Pig_ DAPK1 ( ortholog_one2one ) Rat_ Dapk1 ( ortholog_one2one ) Rabbit_ DAPK1 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | DAPK2, DAPK3, MYLK, NEXN |
| Tissue | NA |
| Tissue Specificity | Isoform 2 is expressed in normal intestinal tissue as well as in colorectal carcinomas. {ECO:0000269|PubMed:18422656}. |
| Pharmacological Animal Models | 0.000730(Chimpanzee);NULL(Mouse);NULL(Rat);NULL(Rabbit) |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
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| PDB | 1IG1 (X-ray 1.80A ) 1JKK (X-ray 2.40A ) 1JKL (X-ray 1.62A ) 1JKS (X-ray 1.50A ) 1JKT (X-ray 3.50A ) 1P4F (X-ray 1.90A ) 1WVW (X-ray 2.40A ) 1WVX (X-ray 2.60A ) 1WVY (X-ray 2.80A ) 1YR5 (X-ray 1.70A ) 2W4J (X-ray 1.30A ) 2W4K (X-ray 1.90A ) 2X0G (X-ray 2.20A ) 2XUU (X-ray 1.80A ) 2XZS (X-ray 2.00A ) 2Y0A (X-ray 2.60A ) 2Y4P (X-ray 2.65A ) 2Y4V (X-ray 1.80A ) 2YAK (X-ray 2.20A ) 3DFC (X-ray 1.90A ) 3DGK (X-ray 1.70A ) 3EH9 (X-ray 1.70A ) 3EHA (X-ray 1.60A ) 3F5G (X-ray 1.85A ) 3F5U (X-ray 2.00A ) 3GU4 (X-ray 1.35A ) 3GU5 (X-ray 1.65A ) 3GU6 (X-ray 1.49A ) 3GU7 (X-ray 1.90A ) 3GU8 (X-ray 1.60A ) 3GUB (X-ray 1.71A ) 3ZXT (X-ray 2.65A ) 4B4L (X-ray 1.75A ) 4PF4 (X-ray 1.13A ) 4TL0 (X-ray 2.70A ) 4TXC (X-ray 1.95A ) 4UV0 (X-ray 2.49A ) 4YO4 (X-ray 1.60A ) 4YPD (X-ray 1.40A ) 5AUT (X-ray 1.70A ) 5AUU (X-ray 1.70A ) 5AUV (X-ray 1.50A ) 5AUW (X-ray 1.50A ) 5AUX (X-ray 1.50A ) 5AUY (X-ray 2.00A ) 5AUZ (X-ray 1.60A ) 5AV0 (X-ray 1.85A ) 5AV1 (X-ray 1.50A ) 5AV2 (X-ray 1.50A ) 5AV3 (X-ray 1.90A ) 5AV4 (X-ray 1.40A ) 6AAR (X-ray 1.95A ) 6FHA (X-ray 2.30A ) 6FHB (X-ray 1.75A ) 6GY5 (X-ray 1.09A ) 6IN4 (X-ray 1.80A ) 6QMO (X-ray 1.87A ) 6QN4 (X-ray 2.50A ) 7CCU (X-ray 1.65A ) 7CCV (X-ray 1.75A ) 7CCW (X-ray 1.40A ) |
| DBSNP | rs12343465 rs56327474 rs36214022 rs36215047 rs371784492 rs56169226 rs1056719 rs36220450 |
| Subcellular location [CC] | [Isoform 1]: Cytoplasm. Cytoplasm, cytoskeleton. Note=Colocalizes with MAP1B in the microtubules and cortical actin fibers.; [Isoform 2]: Cytoplasm. Cytoplasm, cytoskeleton. |
| Mouse PG classification | NA |
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