| Gene Information | |
|---|---|
| Gene Name | DACAR |
| Organism | Homo sapiens (Human) |
| Gene Length | 537 |
| Protein Names | Caspase recruitment domain-containing protein 8 (EC 3.4.-.-) (CARD-inhibitor of NF-kappa-B-activating ligand) (CARDINAL) (Tumor up-regulated CARD-containing antagonist of CASP9) (TUCAN) [Cleaved into: Caspase recruitment domain-containing protein 8, C-terminus (CARD8-CT); Caspase recruitment domain-containing protein 8, N-terminus (CARD8-NT)] |
| Target Name | NA |
| Target Type | NA |
| Gene Age | NA |
| Evolutionary Stage | NA |
| AlphaFoldDB | Q9Y2G2 |
| Gene Card | CARD8 |
| Uniprot ID | Q9Y2G2 |
| Pfam | PF00619; PF13553 |
| In ASD | no |
| Allosteric Prediction | NA |
| Ortholog in Animals | NA |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | NA |
| Tissue Specificity | High expression in lung, ovary, testis and placenta (PubMed:11551959). Lower expression in heart, kidney and liver (PubMed:11551959). Also expressed in spleen, lymph node and bone marrow (PubMed:11821383). {ECO:0000269|PubMed:11551959, ECO:0000269|PubMed:11821383}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
|
| PDB | 4IKM (X-ray 2.46A ) 6K9F (EM 3.70A ) 6XKJ (EM 3.54A ) 7JKQ (EM 3.30A ) 7JN7 (EM 3.30A ) |
| DBSNP | rs2043211 rs11881179 rs59878320 rs2043211 |
| Subcellular location [CC] | Cytoplasm {ECO:0000269|PubMed:15030775, ECO:0000269|PubMed:24517500, ECO:0000269|PubMed:33154409}. Nucleus {ECO:0000269|PubMed:15030775, ECO:0000269|PubMed:33154409}.; [Caspase recruitment domain-containing protein 8, C-terminus]: Inflammasome {ECO:0000269|PubMed:32840892, ECO:0000269|PubMed:33420028, ECO:0000269|PubMed:33420033, ECO:0000269|PubMed:33542150}. |
| Mouse PG classification | NA |
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