| Gene Information | |
|---|---|
| Gene Name | PSIP1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 530 |
| Protein Names | PC4 and SFRS1-interacting protein (CLL-associated antigen KW-7) (Dense fine speckles 70 kDa protein) (DFS 70) (Lens epithelium-derived growth factor) (Transcriptional coactivator p75/p52) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 645 ( ENSG00000164985 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | O75475 |
| Gene Card | PSIP1 |
| Uniprot ID | O75475 |
| Pfam | PF11467; PF00855 |
| In ASD | yes |
| Allosteric Prediction | yes (0.007292282) |
| Ortholog in Animals | Alpaca_ PSIP1 ( ortholog_one2one ) GuineaPig_ PSIP1 ( ortholog_one2one ) Macaque_ PSIP1 ( ortholog_one2one ) Mouse_ Psip1 ( ortholog_one2one ) Pig_ PSIP1 ( ortholog_one2one ) Rat_ Psip1 ( ortholog_one2one ) Rabbit_ PSIP1 ( ortholog_one2one ) |
| Ohnologs | HDGFL2 |
| Paralogs | HDGF, HDGFL3, HDGFL2, HDGFL1 |
| Tissue | NA |
| Tissue Specificity | Widely expressed. Expressed at high level in the thymus. Expressed in fetal and adult brain. Expressed in neurons, but not astrocytes. Markedly elevated in fetal as compared to adult brain. In the adult brain, expressed in the subventricular zone (SVZ), in hippocampus, and undetectable elsewhere. In the fetal brain, expressed in the germinal neuroepithelium and cortical plate regions. {ECO:0000269|PubMed:15642333, ECO:0000269|PubMed:9822615}. |
| Pharmacological Animal Models | 0.011318(Chimpanzee);0.001000(Mouse);0.001347(Rat);0.014286(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 1Z9E (NMR - ) 2B4J (X-ray 2.02A ) 2M16 (NMR - ) 2MSR (NMR - ) 2MTN (NMR - ) 2N3A (NMR - ) 3F9K (X-ray 3.20A ) 3HPG (X-ray 3.28A ) 3HPH (X-ray 2.64A ) 3U88 (X-ray 3.00A ) 3ZEH (NMR - ) 4FU6 (X-ray 2.10A ) 5N88 (X-ray 1.70A ) 5OYM (X-ray 2.05A ) 5YI9 (NMR - ) 6EMO (NMR - ) 6EMP (NMR - ) 6EMQ (NMR - ) 6EMR (NMR - ) 6S01 (EM 3.20A ) 6TRJ (X-ray 1.30A ) 6TVM (NMR - ) 6ZV0 (NMR - ) 7OUF (EM 3.00A ) 7OUG (EM 3.10A ) 7OUH (EM 3.50A ) 7PEL (EM 3.34A ) 7Z1Z (EM 3.50A ) |
| DBSNP | NA |
| Subcellular location [CC] | Nucleus {ECO:0000269|PubMed:15642333, ECO:0000269|PubMed:9885563}. Note=Remains chromatin-associated throughout the cell cycle. |
| Mouse PG classification | NA |
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