| Gene Information | |
|---|---|
| Gene Name | CYFIP1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 1253 |
| Protein Names | Cytoplasmic FMR1-interacting protein 1 (Specifically Rac1-associated protein 1) (Sra-1) (p140sra-1) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 1064 ( ENSG00000273749 ) 3 ( ENSG00000280618 ) 3 ( ENSG00000288461 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | Q7L576 |
| Gene Card | CYFIP1 |
| Uniprot ID | Q7L576 |
| Pfam | PF07159; PF05994 |
| In ASD | no |
| Allosteric Prediction | yes (0.365478014) |
| Ortholog in Animals | Alpaca_ CYFIP1 ( ortholog_one2one ) Dog_ CYFIP1 ( ortholog_one2one ) GuineaPig_ CYFIP1 ( ortholog_one2one ) Macaque_ CYFIP1 ( ortholog_one2one ) Mouse_ Cyfip1 ( ortholog_one2one ) Pig_ CYFIP1 ( ortholog_one2one ) Rat_ Cyfip1 ( ortholog_one2one ) Rabbit_ CYFIP1 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | CYFIP2 |
| Tissue | NA |
| Tissue Specificity | NA |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);0.118256(Rat);0.025000(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 3P8C (X-ray 2.29A ) 4N78 (X-ray 2.43A ) |
| DBSNP | rs34683919 rs17137190 rs7170637 |
| Subcellular location [CC] | Cytoplasm {ECO:0000250|UniProtKB:Q7TMB8}. Cytoplasm, perinuclear region {ECO:0000250|UniProtKB:Q7TMB8}. Cell projection, lamellipodium {ECO:0000250|UniProtKB:Q7TMB8}. Cell projection, ruffle {ECO:0000250|UniProtKB:Q7TMB8}. Synapse, synaptosome {ECO:0000250|UniProtKB:Q7TMB8}. Note=Highly expressed in the perinuclear region (By similarity). Enriched in synaptosomes (By similarity). Also enriched in membrane ruffles and at the tips of lamellipodia (By similarity). {ECO:0000250|UniProtKB:Q7TMB8}. |
| Mouse PG classification | NA |
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