| Gene Information | |
|---|---|
| Gene Name | CYTH3 |
| Organism | Homo sapiens (Human) |
| Gene Length | 400 |
| Protein Names | Cytohesin-3 (ARF nucleotide-binding site opener 3) (Protein ARNO3) (General receptor of phosphoinositides 1) (Grp1) (PH, SEC7 and coiled-coil domain-containing protein 3) |
| Target Name | cytohesin-3 |
| Target Type | NA |
| Gene Age | >4290 ( ENSG00000008256 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | O43739 |
| Gene Card | CYTH3 |
| Uniprot ID | O43739 |
| Pfam | PF00169; PF01369 |
| In ASD | yes |
| Allosteric Prediction | yes (0.05084591) |
| Ortholog in Animals | Alpaca_ CYTH3 ( ortholog_one2many ) Dog_ CYTH3 ( ortholog_one2one ) GuineaPig_ CYTH3 ( ortholog_one2one ) Macaque_ CYTH3 ( ortholog_one2one ) Mouse_ Cyth3 ( ortholog_one2one ) Pig_ CYTH3 ( ortholog_one2one ) Rat_ Cyth3 ( ortholog_one2one ) |
| Ohnologs | CYTH4, CYTH2, CYTH1 |
| Paralogs | PSD2, PSD3, ARFGEF2, CYTH4, MON2, GBF1, ARFGEF1, PSD, PSD4, FBXO8, CYTH1, IQSEC3, IQSEC1, CYTH2, IQSEC2 |
| Tissue | NA |
| Tissue Specificity | Almost absent from liver, thymus and peripheral blood lymphocytes. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | 4KAX (X-ray 1.85A ) 6U3E (EM 53.00A ) 6U3G (EM 53.00A ) |
| DBSNP | NA |
| Subcellular location [CC] | Cytoplasm, cytosol. Cell membrane {ECO:0000250|UniProtKB:O08967}; Peripheral membrane protein {ECO:0000250|UniProtKB:O08967}. Cell junction, adherens junction {ECO:0000250|UniProtKB:O08967}. Cell junction, tight junction {ECO:0000250|UniProtKB:O08967}. Note=Translocates from the cytosol to membranes enriched in phosphatidylinositol 3,4,5-trisphosphate. {ECO:0000250|UniProtKB:O08967}. |
| Mouse PG classification | NA |
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