| Gene Information | |
|---|---|
| Gene Name | CYS1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 158 |
| Protein Names | Cystin-1 (Cilia-associated protein) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 55 ( ENSG00000205795 ) |
| Evolutionary Stage | Mammalia |
| AlphaFoldDB | Q717R9 |
| Gene Card | CYS1 |
| Uniprot ID | Q717R9 |
| Pfam | NA |
| In ASD | no |
| Allosteric Prediction | no (-1.416656615) |
| Ortholog in Animals | Alpaca_ CYS1 ( ortholog_one2one ) Dog_ CYS1 ( ortholog_one2one ) Macaque_ CYS1 ( ortholog_one2one ) Mouse_ Cys1 ( ortholog_one2one ) Pig_ CYS1 ( ortholog_one2one ) Rat_ Cys1 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | kidney |
| Tissue Specificity | Expressed at high levels in the kidney and pancreas. Moderate expression seen in the skeletal muscle, liver and heart. A weak expression seen in the brain, lung, uterus, prostate, testis, small intestine and colon. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | NA |
| Subcellular location [CC] | Cell projection, cilium membrane {ECO:0000269|PubMed:22085962}; Lipid-anchor {ECO:0000269|PubMed:22085962}. Cytoplasm, cytoskeleton, cilium axoneme {ECO:0000269|PubMed:22085962}. Note=Expression is enriched in the ciliary axoneme. Localization to cilium is mediated via interaction with UNC119 and UNC119B, which bind to the myristoyl moiety of the N-terminus. |
| Mouse PG classification | NA |
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