| Gene Information | |
|---|---|
| Gene Name | CYP8 |
| Organism | Homo sapiens (Human) |
| Gene Length | 500 |
| Protein Names | Prostacyclin synthase (EC 5.3.99.4) (Hydroperoxy icosatetraenoate dehydratase) (EC 4.2.1.152) (Prostaglandin I2 synthase) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | NA |
| Evolutionary Stage | NA |
| AlphaFoldDB | Q16647 |
| Gene Card | PTGIS |
| Uniprot ID | Q16647 |
| Pfam | PF00067 |
| In ASD | no |
| Allosteric Prediction | NA |
| Ortholog in Animals | NA |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | NA |
| Tissue Specificity | Widely expressed; particularly abundant in ovary, heart, skeletal muscle, lung and prostate. {ECO:0000269|PubMed:8185632}. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);NULL(Rat);0.022222(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 2IAG (X-ray 2.15A ) 3B6H (X-ray 1.62A ) |
| DBSNP | rs1173082660 rs5622 rs5623 rs5624 rs5626 rs56195291 rs146531327 rs5584 |
| Subcellular location [CC] | Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q29626}; Single-pass membrane protein {ECO:0000255}. |
| Mouse PG classification | NA |
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