| Gene Information | |
|---|---|
| Gene Name | CYP46 |
| Organism | Homo sapiens (Human) |
| Gene Length | 500 |
| Protein Names | Cholesterol 24-hydroxylase (CH24H) (EC 1.14.14.25) (Cholesterol 24-monooxygenase) (Cholesterol 24S-hydroxylase) (Cytochrome P450 46A1) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | NA |
| Evolutionary Stage | NA |
| AlphaFoldDB | Q9Y6A2 |
| Gene Card | CYP46A1 |
| Uniprot ID | Q9Y6A2 |
| Pfam | PF00067 |
| In ASD | yes |
| Allosteric Prediction | NA |
| Ortholog in Animals | NA |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | NA |
| Tissue Specificity | Expressed in brain. The mRNA was broadly distributed with higher levels in gray matter zones and lower levels in regions rich in white matter. Not detected in fetal sample but its expression increases linearly with age. {ECO:0000269|PubMed:10377398}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 2Q9F (X-ray 1.90A ) 2Q9G (X-ray 2.40A ) 3MDM (X-ray 1.60A ) 3MDR (X-ray 2.00A ) 3MDT (X-ray 2.30A ) 3MDV (X-ray 2.40A ) 4ENH (X-ray 2.50A ) 4FIA (X-ray 2.10A ) 4J14 (X-ray 2.50A ) 7LRL (X-ray 2.00A ) 7LS3 (X-ray 2.15A ) 7LS4 (X-ray 2.05A ) 7N3L (X-ray 1.63A ) 7N3M (X-ray 1.70A ) 7N6F (X-ray 1.40A ) |
| DBSNP | NA |
| Subcellular location [CC] | Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q9WVK8}; Single-pass membrane protein {ECO:0000250|UniProtKB:Q9WVK8}. Microsome membrane {ECO:0000250|UniProtKB:Q9WVK8}; Single-pass membrane protein {ECO:0000250|UniProtKB:Q9WVK8}. Postsynapse {ECO:0000250|UniProtKB:Q9WVK8}. Presynapse {ECO:0000250|UniProtKB:Q9WVK8}. Cell projection, dendrite {ECO:0000250|UniProtKB:Q9WVK8}. |
| Mouse PG classification | NA |
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