Gene Information
Gene NameCYP2C9
OrganismHomo sapiens (Human)
Gene Length490
Protein NamesCytochrome P450 2C9 (EC 1.14.14.1) ((R)-limonene 6-monooxygenase) (EC 1.14.14.53) ((S)-limonene 6-monooxygenase) (EC 1.14.14.51) ((S)-limonene 7-monooxygenase) (EC 1.14.14.52) (CYPIIC9) (Cholesterol 25-hydroxylase) (Cytochrome P-450MP) (Cytochrome P450 MP-4) (Cytochrome P450 MP-8) (Cytochrome P450 PB-1) (S-mephenytoin 4-hydroxylase)
Target Names-mephenytoin 4-hydroxylase
Target TypeSuccessful target
Gene Age78 ( ENSG00000138109 )
Evolutionary StageEukaryota
AlphaFoldDBP11712
Gene CardCYP2C9
Uniprot IDP11712
PfamPF00067
In ASDyes
Allosteric Predictionyes (1.000059827)
Ortholog in AnimalsAlpaca_ CYP2C9 ( ortholog_one2one )
Macaque_ CYP2C18 ( ortholog_one2one )
OhnologsCYP2U1
ParalogsCYP2C19, CYP2S1, CYP2W1, CYP2D6, CYP2C18, CYP2B6, CYP2C8, CYP2U1, CYP2A6, CYP2A7, CYP2A13, CYP2F1, CYP2R1, CYP2E1, CYP2J2
Tissueliver, small.intestine
Tissue SpecificityNA
Pharmacological Animal ModelsNA
Gene Ontology
(biological process)
Gene Ontology
(cellular component)
Gene Ontology
(molecular function)
PDB 1OG2  (X-ray  2.60A  )  1OG5  (X-ray  2.55A  )  1R9O  (X-ray  2.00A  )  4NZ2  (X-ray  2.45A  )  5A5I  (X-ray  2.00A  )  5A5J  (X-ray  2.90A  )  5K7K  (X-ray  2.30A  )  5W0C  (X-ray  2.00A  )  5X23  (X-ray  2.00A  )  5X24  (X-ray  2.48A  )  5XXI  (X-ray  2.30A  )  6VLT  (X-ray  3.12A  )  7RL2  (X-ray  2.23A  ) 
DBSNP rs67807361  rs72558189  rs72558189  rs1799853  rs7900194  rs2256871  rs9332130  rs28371685  rs1057909  rs1057910  rs56165452  rs28371686  rs28371687  rs9332239 
Subcellular location [CC]Endoplasmic reticulum membrane;
Peripheral membrane protein. Microsome membrane {ECO:0000269|PubMed:21576599};
Peripheral membrane protein.
Mouse PG classificationNA
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