| Gene Information | |
|---|---|
| Gene Name | CYP27C1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 542 |
| Protein Names | Cytochrome P450 27C1 (EC 1.14.19.53) (All-trans retinol 3,4-desaturase) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 645 ( ENSG00000186684 ) |
| Evolutionary Stage | Euk+Bac |
| AlphaFoldDB | Q4G0S4 |
| Gene Card | CYP27C1 |
| Uniprot ID | Q4G0S4 |
| Pfam | PF00067 |
| In ASD | no |
| Allosteric Prediction | no (-0.478296386) |
| Ortholog in Animals | Dog_ CYP27C1 ( ortholog_one2one ) Macaque_ CYP27C1 ( ortholog_one2one ) Rabbit_ CYP27C1 ( ortholog_one2one ) |
| Ohnologs | CYP27B1, CYP27A1 |
| Paralogs | CYP27A1, CYP27B1, CYP24A1 |
| Tissue | NA |
| Tissue Specificity | Widely expressed, with highest levels in the liver, kidney and pancreas. {ECO:0000269|PubMed:16360114}.; [Isoform 2]: Expressed in the skin (at protein level). {ECO:0000269|PubMed:28701464}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | rs35075135 |
| Subcellular location [CC] | [Isoform 2]: Mitochondrion membrane {ECO:0000250|UniProtKB:P14137}; Peripheral membrane protein {ECO:0000250|UniProtKB:P14137}. |
| Mouse PG classification | NA |
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