| Gene Information | |
|---|---|
| Gene Name | CYP1B1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 543 |
| Protein Names | Cytochrome P450 1B1 (EC 1.14.14.1) (CYPIB1) (Hydroperoxy icosatetraenoate dehydratase) (EC 4.2.1.152) |
| Target Name | cytochrome p450 1b1 |
| Target Type | NA |
| Gene Age | 680 ( ENSG00000138061 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | Q16678 |
| Gene Card | CYP1B1 |
| Uniprot ID | Q16678 |
| Pfam | PF00067 |
| In ASD | no |
| Allosteric Prediction | yes (0.854718078) |
| Ortholog in Animals | Alpaca_ CYP1B1 ( ortholog_one2one ) Dog_ CYP1B1 ( ortholog_one2one ) GuineaPig_ CYP1B1 ( ortholog_one2one ) Macaque_ CYP1B1 ( ortholog_one2one ) Mouse_ Cyp1b1 ( ortholog_one2one ) Pig_ CYP1B1 ( ortholog_one2one ) Rat_ Cyp1b1 ( ortholog_one2one ) Rabbit_ CYP1B1 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | CYP1A1, CYP1A2 |
| Tissue | NA |
| Tissue Specificity | Expressed in heart, brain, lung, skeletal muscle, kidney, spleen, thymus, prostate, testis, ovary, small intestine, colon, and peripheral blood leukocytes (PubMed:8175734). Expressed in retinal endothelial cells and umbilical vein endothelial cells (at protein level) (PubMed:19005183). {ECO:0000269|PubMed:19005183, ECO:0000269|PubMed:8175734}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | 3PM0 (X-ray 2.70A ) 6IQ5 (X-ray 3.70A ) |
| DBSNP | rs780002791 rs10012 rs201824781 rs72549387 rs28936700 rs9282670 rs9282671 rs764338357 rs1056827 rs753847648 rs1326854156 rs529769268 rs59472972 rs1426636145 rs9341248 rs72549384 rs57865060 rs104893628 rs9341250 rs72549382 rs752456881 rs66583685 rs72549379 rs55771538 rs79204362 rs104893622 rs56305281 rs55989760 rs148542782 rs56010818 rs148542782 rs72549378 rs957253424 rs104893629 rs1056836 rs56175199 rs4986887 rs4986888 rs72549376 rs1056837 rs1800440 rs868208502 rs28936701 rs72549372 |
| Subcellular location [CC] | Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q64429}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q64429}. Microsome membrane {ECO:0000250|UniProtKB:Q64429}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q64429}. Mitochondrion {ECO:0000250|UniProtKB:Q64429}. Note=Located primarily in endoplasmic reticulum. Upon treatment with 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), CYP1B1 is also targeted to mitochondria. {ECO:0000250|UniProtKB:Q64429}. |
| Mouse PG classification | HPG |
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