Gene Information
Gene NameCYP1B1
OrganismHomo sapiens (Human)
Gene Length543
Protein NamesCytochrome P450 1B1 (EC 1.14.14.1) (CYPIB1) (Hydroperoxy icosatetraenoate dehydratase) (EC 4.2.1.152)
Target Namecytochrome p450 1b1
Target TypeClinical trial target
Gene Age680 ( ENSG00000138061 )
Evolutionary StageEukaryota
AlphaFoldDBQ16678
Gene CardCYP1B1
Uniprot IDQ16678
PfamPF00067
In ASDno
Allosteric Predictionyes (0.854718078)
Ortholog in AnimalsAlpaca_ CYP1B1 ( ortholog_one2one )
Dog_ CYP1B1 ( ortholog_one2one )
GuineaPig_ CYP1B1 ( ortholog_one2one )
Macaque_ CYP1B1 ( ortholog_one2one )
Mouse_ Cyp1b1 ( ortholog_one2one )
Pig_ CYP1B1 ( ortholog_one2one )
Rat_ Cyp1b1 ( ortholog_one2one )
Rabbit_ CYP1B1 ( ortholog_one2one )
OhnologsNA
ParalogsCYP1A1, CYP1A2
TissueNA
Tissue SpecificityExpressed in heart, brain, lung, skeletal muscle, kidney, spleen, thymus, prostate, testis, ovary, small intestine, colon, and peripheral blood leukocytes (PubMed:8175734). Expressed in retinal endothelial cells and umbilical vein endothelial cells (at protein level) (PubMed:19005183). {ECO:0000269|PubMed:19005183, ECO:0000269|PubMed:8175734}.
Pharmacological Animal ModelsNA
Gene Ontology
(biological process)
Gene Ontology
(cellular component)
Gene Ontology
(molecular function)
PDB 3PM0  (X-ray  2.70A  )  6IQ5  (X-ray  3.70A  ) 
DBSNP rs780002791  rs10012  rs201824781  rs72549387  rs28936700  rs9282670  rs9282671  rs764338357  rs1056827  rs753847648  rs1326854156  rs529769268  rs59472972  rs1426636145  rs9341248  rs72549384  rs57865060  rs104893628  rs9341250  rs72549382  rs752456881  rs66583685  rs72549379  rs55771538  rs79204362  rs104893622  rs56305281  rs55989760  rs148542782  rs56010818  rs148542782  rs72549378  rs957253424  rs104893629  rs1056836  rs56175199  rs4986887  rs4986888  rs72549376  rs1056837  rs1800440  rs868208502  rs28936701  rs72549372 
Subcellular location [CC]Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q64429};
Peripheral membrane protein {ECO:0000250|UniProtKB:Q64429}. Microsome membrane {ECO:0000250|UniProtKB:Q64429};
Peripheral membrane protein {ECO:0000250|UniProtKB:Q64429}. Mitochondrion {ECO:0000250|UniProtKB:Q64429}. Note=Located primarily in endoplasmic reticulum. Upon treatment with 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), CYP1B1 is also targeted to mitochondria. {ECO:0000250|UniProtKB:Q64429}.
Mouse PG classificationHPG
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