| Gene Information | |
|---|---|
| Gene Name | CYP19A1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 503 |
| Protein Names | Aromatase (EC 1.14.14.14) (CYPXIX) (Cytochrome P-450AROM) (Cytochrome P450 19A1) (Estrogen synthase) |
| Target Name | aromatase |
| Target Type | Successful target |
| Gene Age | 680 ( ENSG00000137869 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | P11511 |
| Gene Card | CYP19A1 |
| Uniprot ID | P11511 |
| Pfam | PF00067 |
| In ASD | yes |
| Allosteric Prediction | yes (0.999782046) |
| Ortholog in Animals | Alpaca_ CYP19A1 ( ortholog_one2one ) Dog_ CYP19A1 ( ortholog_one2one ) GuineaPig_ CYP19A1 ( ortholog_one2one ) Macaque_ CYP19A1 ( ortholog_one2one ) Mouse_ Cyp19a1 ( ortholog_one2one ) Rat_ Cyp19a1 ( ortholog_one2one ) Rabbit_ CYP19A1 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | CYP4F12, CYP4A22, CYP4A11, CYP4B1, CYP4F8, CYP4F11, CYP4F2, CYP4F22, CYP4X1, CYP4Z1, CYP4F3, CYP4V2 |
| Tissue | placenta, ovary |
| Tissue Specificity | Widely expressed, including in adult and fetal brain, placenta, skin fibroblasts, adipose tissue and gonads. {ECO:0000269|PubMed:2040633, ECO:0000269|PubMed:3018730, ECO:0000269|PubMed:7690033, ECO:0000269|PubMed:8117272}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | 3EQM (X-ray 2.90A ) 3S79 (X-ray 2.75A ) 3S7S (X-ray 3.21A ) 4GL5 (X-ray 3.48A ) 4GL7 (X-ray 3.90A ) 4KQ8 (X-ray 3.29A ) 5JKV (X-ray 2.75A ) 5JKW (X-ray 3.00A ) 5JL6 (X-ray 3.00A ) 5JL7 (X-ray 3.10A ) 5JL9 (X-ray 3.10A ) |
| DBSNP | rs2236722 rs765057534 rs28757184 rs700519 rs2304462 rs80051519 rs121434536 rs762631156 rs121434534 rs78310315 |
| Subcellular location [CC] | Endoplasmic reticulum membrane {ECO:0000269|PubMed:2973313}; Multi-pass membrane protein {ECO:0000305}. Microsome membrane {ECO:0000269|PubMed:2973313}; Multi-pass membrane protein {ECO:0000305}. |
| Mouse PG classification | NA |
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