| Gene Information | |
|---|---|
| Gene Name | CYM |
| Organism | Homo sapiens (Human) |
| Gene Length | 247 |
| Protein Names | Chymase (EC 3.4.21.39) (Alpha-chymase) (Mast cell protease I) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | NA |
| Evolutionary Stage | NA |
| AlphaFoldDB | P23946 |
| Gene Card | CMA1 |
| Uniprot ID | P23946 |
| Pfam | PF00089 |
| In ASD | no |
| Allosteric Prediction | NA |
| Ortholog in Animals | NA |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | NA |
| Tissue Specificity | Mast cells in lung, heart, skin and placenta. Expressed in both normal skin and in urticaria pigmentosa lesions. {ECO:0000269|PubMed:8144971}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 1KLT (X-ray 1.90A ) 1NN6 (X-ray 1.75A ) 1PJP (X-ray 2.20A ) 1T31 (X-ray 1.90A ) 2HVX (X-ray 2.60A ) 3N7O (X-ray 1.80A ) 3S0N (X-ray 1.95A ) 4AFQ (X-ray 1.51A ) 4AFS (X-ray 1.90A ) 4AFU (X-ray 1.82A ) 4AFZ (X-ray 2.25A ) 4AG1 (X-ray 1.40A ) 4AG2 (X-ray 1.80A ) 4K2Y (X-ray 2.30A ) 4K5Z (X-ray 1.80A ) 4K60 (X-ray 1.50A ) 4K69 (X-ray 1.50A ) 4KP0 (X-ray 2.80A ) 5YJM (X-ray 1.90A ) 5YJP (X-ray 1.80A ) |
| DBSNP | rs5246 rs5247 rs13306252 |
| Subcellular location [CC] | Secreted. Cytoplasmic granule. Note=Mast cell granules. |
| Mouse PG classification | NA |
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