| Gene Information | |
|---|---|
| Gene Name | CYLD |
| Organism | Homo sapiens (Human) |
| Gene Length | 956 |
| Protein Names | Ubiquitin carboxyl-terminal hydrolase CYLD (EC 3.4.19.12) (Deubiquitinating enzyme CYLD) (Ubiquitin thioesterase CYLD) (Ubiquitin-specific-processing protease CYLD) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 645 ( ENSG00000083799 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | Q9NQC7 |
| Gene Card | CYLD |
| Uniprot ID | Q9NQC7 |
| Pfam | PF01302; PF00443 |
| In ASD | no |
| Allosteric Prediction | yes (0.155177321) |
| Ortholog in Animals | Alpaca_ CYLD ( ortholog_one2one ) Dog_ CYLD ( ortholog_one2one ) GuineaPig_ CYLD ( ortholog_one2one ) Macaque_ CYLD ( ortholog_one2one ) Mouse_ Cyld ( ortholog_one2one ) Pig_ CYLD ( ortholog_one2one ) Rat_ Cyld-ps1 ( ortholog_one2many ) Rat_ Cyld ( ortholog_one2many ) Rabbit_ CYLD ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | NA |
| Tissue Specificity | Detected in fetal brain, testis, and skeletal muscle, and at a lower level in adult brain, leukocytes, liver, heart, kidney, spleen, ovary and lung. Isoform 2 is found in all tissues except kidney. {ECO:0000269|PubMed:10835629, ECO:0000269|PubMed:29291351}. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);0.002190(Rat);NULL(Rabbit) |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | 1IXD (NMR - ) 1WHL (NMR - ) 1WHM (NMR - ) 2VHF (X-ray 2.80A ) 7OWD (X-ray 1.71A ) |
| DBSNP | rs751380834 rs121908389 |
| Subcellular location [CC] | Cytoplasm {ECO:0000269|PubMed:18313383, ECO:0000269|PubMed:32185393}. Cytoplasm, perinuclear region. Cytoplasm, cytoskeleton. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:25134987}. Cytoplasm, cytoskeleton, spindle {ECO:0000269|PubMed:25134987}. Cytoplasm, cytoskeleton, cilium basal body {ECO:0000250|UniProtKB:Q80TQ2}. Note=Detected at the microtubule cytoskeleton during interphase. Detected at the midbody during telophase. During metaphase, it remains localized to the centrosome but is also present along the spindle (PubMed:25134987). {ECO:0000250|UniProtKB:Q80TQ2, ECO:0000269|PubMed:25134987}. |
| Mouse PG classification | NA |
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