| Gene Information | |
|---|---|
| Gene Name | AICDA |
| Organism | Homo sapiens (Human) |
| Gene Length | 198 |
| Protein Names | Single-stranded DNA cytosine deaminase (EC 3.5.4.38) (Activation-induced cytidine deaminase) (AID) (Cytidine aminohydrolase) |
| Target Name | cytosine deaminase |
| Target Type | Clinical trial target |
| Gene Age | 454 ( ENSG00000111732 ) |
| Evolutionary Stage | Vertebrata |
| AlphaFoldDB | Q9GZX7 |
| Gene Card | AICDA |
| Uniprot ID | Q9GZX7 |
| Pfam | NA |
| In ASD | no |
| Allosteric Prediction | yes (0.110964123) |
| Ortholog in Animals | Alpaca_ AICDA ( ortholog_one2one ) Dog_ AICDA ( ortholog_one2one ) Macaque_ AICDA ( ortholog_one2one ) Mouse_ Aicda ( ortholog_one2one ) Pig_ AICDA ( ortholog_one2one ) Rat_ Aicda ( ortholog_one2one ) Rabbit_ AICDA ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | APOBEC3B, APOBEC3A, APOBEC2, APOBEC3H, APOBEC3C, APOBEC3F, APOBEC3D, APOBEC3G, APOBEC1 |
| Tissue | lymph.node |
| Tissue Specificity | Strongly expressed in lymph nodes and tonsils. {ECO:0000269|PubMed:23166356}. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);NULL(Rat);0.06875(Rabbit) |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | 5JJ4 (X-ray 2.81A ) 5W0R (X-ray 2.40A ) 5W0U (X-ray 2.90A ) 5W0Z (X-ray 3.61A ) 5W1C (X-ray 3.18A ) |
| DBSNP | rs104894324 rs1404944797 rs104894320 rs762590894 rs104894321 rs104894322 rs104894327 |
| Subcellular location [CC] | Nucleus {ECO:0000269|PubMed:21385873, ECO:0000269|PubMed:32484799}. Cytoplasm, cytosol {ECO:0000269|PubMed:18722174, ECO:0000269|PubMed:21385873, ECO:0000269|PubMed:23166356, ECO:0000269|PubMed:32484799}. Note=Predominantly cytosolic (PubMed:21385873). In the presence of MCM3AP/GANP, relocalizes to the nucleus (By similarity). {ECO:0000250|UniProtKB:Q9WVE0, ECO:0000269|PubMed:21385873}. |
| Mouse PG classification | HPG |
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