| Gene Information | |
|---|---|
| Gene Name | CYBB |
| Organism | Homo sapiens (Human) |
| Gene Length | 570 |
| Protein Names | Cytochrome b-245 heavy chain (EC 1.-.-.-) (CGD91-phox) (Cytochrome b(558) subunit beta) (Cytochrome b558 subunit beta) (Heme-binding membrane glycoprotein gp91phox) (NADPH oxidase 2) (Neutrophil cytochrome b 91 kDa polypeptide) (Superoxide-generating NADPH oxidase heavy chain subunit) (gp91-1) (gp91-phox) (p22 phagocyte B-cytochrome) |
| Target Name | nadph oxidase |
| Target Type | NA |
| Gene Age | 645 ( ENSG00000165168 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | P04839 |
| Gene Card | CYBB |
| Uniprot ID | P04839 |
| Pfam | PF08022; PF01794; PF08030 |
| In ASD | no |
| Allosteric Prediction | yes (0.956587457) |
| Ortholog in Animals | Alpaca_ CYBB ( ortholog_one2one ) Dog_ CYBB ( ortholog_one2one ) GuineaPig_ CYBB ( ortholog_one2one ) Macaque_ CYBB ( ortholog_one2one ) Mouse_ Cybb ( ortholog_one2one ) Pig_ CYBB ( ortholog_one2one ) Rat_ Cybb ( ortholog_one2one ) Rabbit_ CYBB ( ortholog_one2one ) |
| Ohnologs | NOX1, NOX3 |
| Paralogs | NOX3, NOX1, DUOX1, NOX5, NOX4, DUOX2 |
| Tissue | NA |
| Tissue Specificity | Detected in neutrophils (at protein level). {ECO:0000269|PubMed:19028840}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
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| PDB | 3A1F (X-ray 2.00A ) |
| DBSNP | rs151344455 rs151344453 rs151344479 rs151344456 rs151344480 rs151344481 rs151344457 rs151344488 rs137854591 rs137854594 rs151344458 rs137854590 rs151344497 rs151344491 rs151344493 rs151344496 rs151344459 rs151344482 rs137854587 rs151344460 rs151344462 rs151344460 rs151344464 rs151344483 rs151344494 rs151344498 rs151344465 rs137854589 rs137854589 rs137854595 rs137854596 rs151344489 rs151344466 rs151344467 rs151344468 rs151344469 rs151344484 rs151344470 rs151344495 rs151344485 rs151344471 rs141756032 rs137854586 rs137854586 rs151344472 rs151344474 rs151344473 rs137854585 rs137854585 rs151344486 rs151344475 rs151344476 rs13306300 rs137854593 rs151344490 rs151344477 rs151344487 rs151344452 rs151344478 rs151344454 rs151344492 |
| Subcellular location [CC] | Cell membrane; Multi-pass membrane protein. Note=As unassembled monomer may localize to the endoplasmic reticulum. {ECO:0000305|PubMed:28351984}. |
| Mouse PG classification | LPG |
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