| Gene Information | |
|---|---|
| Gene Name | IKZF4 |
| Organism | Homo sapiens (Human) |
| Gene Length | 585 |
| Protein Names | Zinc finger protein Eos (Ikaros family zinc finger protein 4) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 645 ( ENSG00000123411 ) |
| Evolutionary Stage | Opisthokonta |
| AlphaFoldDB | Q9H2S9 |
| Gene Card | IKZF4 |
| Uniprot ID | Q9H2S9 |
| Pfam | PF00096 |
| In ASD | no |
| Allosteric Prediction | no (-0.950842275) |
| Ortholog in Animals | Alpaca_ IKZF4 ( ortholog_one2one ) Dog_ IKZF4 ( ortholog_one2one ) GuineaPig_ IKZF4 ( ortholog_one2one ) Macaque_ IKZF4 ( ortholog_one2one ) Mouse_ Ikzf4 ( ortholog_one2one ) Pig_ IKZF4 ( ortholog_one2one ) Rat_ Ikzf4 ( ortholog_one2one ) Rabbit_ IKZF4 ( ortholog_one2one ) |
| Ohnologs | IKZF3, IKZF2, IKZF1 |
| Paralogs | ZNF613, ZNF649, ZNF821, IKZF1, ZNF567, ZNF639, ZNF382, IKZF3, ZNF350, ZNF564, IKZF2 |
| Tissue | NA |
| Tissue Specificity | Highly expressed in skeletal muscle, low levels of expression in heart, thymus, kidney, liver, and spleen. Expressed in the hematopoietic cell lines MOLT-4, NALM-6 and K-562. Highly expressed in THP-1 and M-07e cell lines, which have characteristics of myeloid and early megakaryocytic cells respectively. {ECO:0000269|PubMed:10978333}. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);NULL(Rat);0.133333(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 2MA7 (NMR - ) |
| DBSNP | NA |
| Subcellular location [CC] | Nucleus {ECO:0000269|PubMed:12444977}. |
| Mouse PG classification | NA |
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