| Gene Information | |
|---|---|
| Gene Name | CXCR4 |
| Organism | Homo sapiens (Human) |
| Gene Length | 352 |
| Protein Names | C-X-C chemokine receptor type 4 (CXC-R4) (CXCR-4) (FB22) (Fusin) (HM89) (LCR1) (Leukocyte-derived seven transmembrane domain receptor) (LESTR) (Lipopolysaccharide-associated protein 3) (LAP-3) (LPS-associated protein 3) (NPYRL) (Stromal cell-derived factor 1 receptor) (SDF-1 receptor) (CD antigen CD184) |
| Target Name | c-x-c chemokine receptor type 4 |
| Target Type | Successful target |
| Gene Age | 645 ( ENSG00000121966 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | P61073 |
| Gene Card | CXCR4 |
| Uniprot ID | P61073 |
| Pfam | PF00001; PF12109 |
| In ASD | yes |
| Allosteric Prediction | yes (1.98563956) |
| Ortholog in Animals | Alpaca_ CXCR4 ( ortholog_one2one ) Dog_ CXCR4 ( ortholog_one2many ) GuineaPig_ CXCR4 ( ortholog_one2one ) Macaque_ CXCR4 ( ortholog_one2one ) Mouse_ Cxcr4 ( ortholog_one2one ) Pig_ CXCR4 ( ortholog_one2one ) Rat_ Cxcr4 ( ortholog_one2one ) Rabbit_ CXCR4 ( ortholog_one2one ) |
| Ohnologs | CCR7, APLNR, AGTR1, CX3CR1, CCR9, CCR8, CCR3, CCR4 |
| Paralogs | GALR2, XCR1, RGR, ACKR3, CCRL2, CCR8, CCR1, ACKR2, CCR4, CX3CR1, CCR2, CCR5, CCR3, CCR9, CXCR6, CCR7, CCR6, ACKR4, CCR10, CXCR5, CXCR1, CXCR2, CXCR3 |
| Tissue | NA |
| Tissue Specificity | Expressed in numerous tissues, such as peripheral blood leukocytes, spleen, thymus, spinal cord, heart, placenta, lung, liver, skeletal muscle, kidney, pancreas, cerebellum, cerebral cortex and medulla (in microglia as well as in astrocytes), brain microvascular, coronary artery and umbilical cord endothelial cells. Isoform 1 is predominant in all tissues tested. {ECO:0000269|PubMed:11276205}. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);0.001000(Rat);0.013333(Rabbit) |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | 2K03 (NMR - ) 2K04 (NMR - ) 2K05 (NMR - ) 2N55 (NMR - ) 3ODU (X-ray 2.50A ) 3OE0 (X-ray 2.90A ) 3OE6 (X-ray 3.20A ) 3OE8 (X-ray 3.10A ) 3OE9 (X-ray 3.10A ) 4RWS (X-ray 3.10A ) |
| DBSNP | NA |
| Subcellular location [CC] | Cell membrane {ECO:0000269|PubMed:10452968, ECO:0000305|PubMed:20929726}; Multi-pass membrane protein {ECO:0000269|PubMed:20929726}. Cell junction. Early endosome. Late endosome. Lysosome. Note=In unstimulated cells, diffuse pattern on plasma membrane. On agonist stimulation, colocalizes with ITCH at the plasma membrane where it becomes ubiquitinated. In the presence of antigen, distributes to the immunological synapse forming at the T-cell-APC contact area, where it localizes at the peripheral and distal supramolecular activation cluster (SMAC). |
| Mouse PG classification | NA |
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