| Gene Information | |
|---|---|
| Gene Name | CXCR3 |
| Organism | Homo sapiens (Human) |
| Gene Length | 368 |
| Protein Names | C-X-C chemokine receptor type 3 (CXC-R3) (CXCR-3) (CKR-L2) (G protein-coupled receptor 9) (Interferon-inducible protein 10 receptor) (IP-10 receptor) (CD antigen CD183) |
| Target Name | c-x-c chemokine receptor type 3 |
| Target Type | Preclinical target |
| Gene Age | 454 ( ENSG00000186810 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | P49682 |
| Gene Card | CXCR3 |
| Uniprot ID | P49682 |
| Pfam | PF00001 |
| In ASD | yes |
| Allosteric Prediction | yes (1.050947418) |
| Ortholog in Animals | Alpaca_ CXCR3 ( ortholog_one2one ) Dog_ CXCR3 ( ortholog_one2one ) GuineaPig_ CXCR3 ( ortholog_one2one ) Macaque_ CXCR3 ( ortholog_one2one ) Mouse_ Cxcr3 ( ortholog_one2one ) Pig_ CXCR3 ( ortholog_one2one ) Rat_ Cxcr3 ( ortholog_one2one ) Rabbit_ CXCR3 ( ortholog_one2one ) |
| Ohnologs | CCR2, ACKR3, ACKR2, CXCR1, CXCR2, CCR4 |
| Paralogs | GALR2, XCR1, RGR, ACKR3, CCRL2, CCR8, CCR1, ACKR2, CCR4, CX3CR1, CCR2, CCR5, CCR3, CCR9, CXCR6, CCR7, CCR6, ACKR4, CCR10, CXCR5, CXCR1, CXCR2, CXCR4 |
| Tissue | appendix, lymph.node, spleen |
| Tissue Specificity | Isoform 1 and isoform 2 are mainly expressed in heart, kidney, liver and skeletal muscle. Isoform 1 is also expressed in placenta. Isoform 2 is expressed in endothelial cells. Expressed in T-cells (at protein level). {ECO:0000269|PubMed:12782716, ECO:0000269|PubMed:23121557}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | NA |
| DBSNP | rs139226823 rs766348940 |
| Subcellular location [CC] | [Isoform 1]: Cell membrane {ECO:0000269|PubMed:12782716}; Multi-pass membrane protein {ECO:0000269|PubMed:12782716}.; [Isoform 2]: Cell membrane {ECO:0000269|PubMed:12782716}; Multi-pass membrane protein {ECO:0000269|PubMed:12782716}. |
| Mouse PG classification | NA |
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