| Gene Information | |
|---|---|
| Gene Name | CXCR1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 350 |
| Protein Names | C-X-C chemokine receptor type 1 (CXC-R1) (CXCR-1) (CDw128a) (High affinity interleukin-8 receptor A) (IL-8R A) (IL-8 receptor type 1) (CD antigen CD181) |
| Target Name | c-x-c chemokine receptor type 1 |
| Target Type | Successful target |
| Gene Age | 454 ( ENSG00000163464 ) |
| Evolutionary Stage | Mammalia |
| AlphaFoldDB | P25024 |
| Gene Card | CXCR1 |
| Uniprot ID | P25024 |
| Pfam | PF00001 |
| In ASD | yes |
| Allosteric Prediction | yes (1.245135991) |
| Ortholog in Animals | Alpaca_ CXCR1 ( ortholog_one2one ) Dog_ CXCR2 ( ortholog_many2many ) GuineaPig_ Cxcr1 ( ortholog_one2one ) Macaque_ CXCR1 ( ortholog_one2one ) Mouse_ Cxcr1 ( ortholog_one2one ) Rat_ Cxcr1 ( ortholog_one2one ) |
| Ohnologs | CCR2, ACKR2, LPAR4, GPR15, CCR4, CCR10, CXCR3 |
| Paralogs | GALR2, XCR1, RGR, ACKR3, CCRL2, CCR8, CCR1, ACKR2, CCR4, CX3CR1, CCR2, CCR5, CCR3, CCR9, CXCR6, CCR7, CCR6, ACKR4, CCR10, CXCR2, CXCR5, CXCR3, CXCR4 |
| Tissue | appendix, spleen, lymph.node, lung, whole.blood |
| Tissue Specificity | NA |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | 1ILP (NMR - ) 1ILQ (NMR - ) 2LNL (NMR - ) 6XMN (NMR - ) |
| DBSNP | rs16858811 rs1805038 rs9282752 rs2234671 rs201583693 rs16858808 rs16858806 |
| Subcellular location [CC] | Cell membrane; Multi-pass membrane protein. |
| Mouse PG classification | NA |
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