Gene Information
Gene NameCXCL8
OrganismHomo sapiens (Human)
Gene Length99
Protein NamesInterleukin-8 (IL-8) (C-X-C motif chemokine 8) (Chemokine (C-X-C motif) ligand 8) (Emoctakin) (Granulocyte chemotactic protein 1) (GCP-1) (Monocyte-derived neutrophil chemotactic factor) (MDNCF) (Monocyte-derived neutrophil-activating peptide) (MONAP) (Neutrophil-activating protein 1) (NAP-1) (Protein 3-10C) (T-cell chemotactic factor) [Cleaved into: MDNCF-a (GCP/IL-8 protein IV) (IL8/NAP1 form I); Interleukin-8 ((Ala-IL-8)77) (GCP/IL-8 protein II) (IL-8(1-77)) (IL8/NAP1 form II) (MDNCF-b); IL-8(5-77); IL-8(6-77) ((Ser-IL-8)72) (GCP/IL-8 protein I) (IL8/NAP1 form III) (Lymphocyte-derived neutrophil-activating factor) (LYNAP) (MDNCF-c) (Neutrophil-activating factor) (NAF); IL-8(7-77) (GCP/IL-8 protein V) (IL8/NAP1 form IV); IL-8(8-77) (GCP/IL-8 protein VI) (IL8/NAP1 form V); IL-8(9-77) (GCP/IL-8 protein III) (IL8/NAP1 form VI)]
Target Nameinterleukin-8
Target TypeSuccessful target
Gene Age544 ( ENSG00000169429 )
Evolutionary StageVertebrata
AlphaFoldDBP10145
Gene CardCXCL8
Uniprot IDP10145
PfamPF00048
In ASDno
Allosteric Predictionyes (0.413674705)
Ortholog in AnimalsAlpaca_ CXCL8 ( ortholog_one2one )
Dog_ CXCL8 ( ortholog_one2one )
GuineaPig_ CXCL8 ( ortholog_one2one )
Macaque_ CXCL8 ( ortholog_one2one )
Pig_ CXCL8 ( ortholog_one2one )
Rabbit_ CXCL8 ( ortholog_one2one )
OhnologsNA
ParalogsCXCL5, CXCL2, CXCL3, CXCL10, CXCL9, CXCL1, CXCL13, CXCL11, CXCL6, PF4, PF4V1, PPBP
Tissuelung, pancreas, whole.blood
Tissue SpecificityNA
Pharmacological Animal ModelsNA
Gene Ontology
(biological process)
Gene Ontology
(cellular component)
Gene Ontology
(molecular function)
PDB 1ICW  (X-ray  2.01A  )  1IKL  (NMR  -  )  1IKM  (NMR  -  )  1IL8  (NMR  -  )  1ILP  (NMR  -  )  1ILQ  (NMR  -  )  1QE6  (X-ray  2.35A  )  1ROD  (NMR  -  )  2IL8  (NMR  -  )  3IL8  (X-ray  2.00A  )  4XDX  (X-ray  0.95A  )  5D14  (X-ray  1.00A  )  5WDZ  (NMR  -  )  6LFM  (EM  3.50A  )  6LFO  (EM  3.40A  )  6N2U  (X-ray  1.25A  )  6WZM  (X-ray  2.28A  )  6XMN  (NMR  -  ) 
DBSNP NA 
Subcellular location [CC]Secreted.
Mouse PG classificationNA
click here to return to the previous page