| Gene Information | |
|---|---|
| Gene Name | CXCL10 |
| Organism | Homo sapiens (Human) |
| Gene Length | 98 |
| Protein Names | C-X-C motif chemokine 10 (10 kDa interferon gamma-induced protein) (Gamma-IP10) (IP-10) (Small-inducible cytokine B10) [Cleaved into: CXCL10(1-73)] |
| Target Name | c-x-c motif chemokine 10 |
| Target Type | Clinical trial target |
| Gene Age | 332 ( ENSG00000169245 ) |
| Evolutionary Stage | Mammalia |
| AlphaFoldDB | P02778 |
| Gene Card | CXCL10 |
| Uniprot ID | P02778 |
| Pfam | PF00048 |
| In ASD | no |
| Allosteric Prediction | yes (0.121903008) |
| Ortholog in Animals | Alpaca_ CXCL10 ( ortholog_one2one ) Dog_ CXCL10 ( ortholog_one2one ) GuineaPig_ CXCL10 ( ortholog_one2one ) Macaque_ CXCL10 ( ortholog_one2one ) Mouse_ Cxcl10 ( ortholog_one2one ) Pig_ CXCL10 ( ortholog_one2one ) Rat_ Cxcl10 ( ortholog_one2one ) Rabbit_ CXCL10 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | CXCL8, CXCL5, CXCL2, CXCL3, CXCL9, CXCL1, CXCL13, CXCL11, CXCL6, PF4, PF4V1, PPBP |
| Tissue | NA |
| Tissue Specificity | Mainly secreted by monocytes, endothelial cells as well as fibroblasts. Expressed by epithelial cells in thymus (PubMed:11157474). Microglial cells produce CXCL10 in response to viral stimulation (PubMed:12663757). {ECO:0000269|PubMed:11157474, ECO:0000269|PubMed:12663757}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | 1LV9 (NMR - ) 1O7Y (X-ray 3.00A ) 1O7Z (X-ray 1.92A ) 1O80 (X-ray 2.00A ) |
| DBSNP | NA |
| Subcellular location [CC] | Secreted {ECO:0000269|PubMed:21183794}. |
| Mouse PG classification | NA |
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