Gene Information
Gene NameCXADR
OrganismHomo sapiens (Human)
Gene Length365
Protein NamesCoxsackievirus and adenovirus receptor (CAR) (hCAR) (CVB3-binding protein) (Coxsackievirus B-adenovirus receptor) (HCVADR)
Target NameNA
Target TypeNA
Gene Age645 ( ENSG00000154639 )
Evolutionary StageEumetazoa
AlphaFoldDBP78310
Gene CardCXADR
Uniprot IDP78310
PfamPF00047; PF07686
In ASDno
Allosteric Predictionyes (0.516453117)
Ortholog in AnimalsAlpaca_ CXADR ( ortholog_one2one )
Dog_ CXADR ( ortholog_one2one )
GuineaPig_ CXADR ( ortholog_one2one )
Macaque_ CXADR ( ortholog_one2one )
Mouse_ Cxadr ( ortholog_one2many )
Mouse_ Gm1123 ( ortholog_one2many )
Pig_ CXADR ( ortholog_one2one )
Rat_ Cxadrl1 ( ortholog_one2many )
Rat_ Cxadr ( ortholog_one2many )
Rabbit_ CXADR ( ortholog_one2one )
OhnologsGPA33
ParalogsMXRA8, VSIG1, IGSF11, JAM3, VSIG2, JAM2, ESAM, F11R, MUC15, GPA33, VSTM2B, VSIR, VSIG8, CLMP
TissueNA
Tissue SpecificityExpressed in pancreas, brain, heart, small intestine, testis, prostate and at a lower level in liver and lung. Isoform 5 is ubiquitously expressed. Isoform 3 is expressed in heart, lung and pancreas. In skeletal muscle, isoform 1 is found at the neuromuscular junction and isoform 2 is found in blood vessels. In cardiac muscle, isoform 1 and isoform 2 are found at intercalated disks. In heart expressed in subendothelial layers of the vessel wall but not in the luminal endothelial surface. Expression is elevated in hearts with dilated cardiomyopathy. {ECO:0000269|PubMed:10490761, ECO:0000269|PubMed:11457744, ECO:0000269|PubMed:11549277, ECO:0000269|PubMed:9096397}.
Pharmacological Animal Models0.000730(Chimpanzee);0.001000(Mouse);0.001000(Rat);NULL(Rabbit)
Gene Ontology
(biological process)
Gene Ontology
(cellular component)
Gene Ontology
(molecular function)
PDB 1EAJ  (X-ray  1.35A  )  1F5W  (X-ray  1.70A  )  1JEW  (EM  22.00A  )  1KAC  (X-ray  2.60A  )  1P69  (X-ray  3.10A  )  1P6A  (X-ray  2.90A  )  1RSF  (NMR  -  )  2J12  (X-ray  1.50A  )  2J1K  (X-ray  2.30A  )  2NPL  (NMR  -  )  2W9L  (X-ray  2.91A  )  2WBW  (X-ray  1.55A  )  3J6L  (EM  9.00A  )  3J6M  (EM  9.00A  )  3J6N  (EM  9.00A  )  3J6O  (EM  9.00A  )  7DPZ  (EM  3.80A  )  7DQ1  (EM  3.60A  )  7VXZ  (EM  3.19A  )  7VYK  (EM  2.79A  )  7VYL  (EM  2.79A  )  7VYM  (EM  3.68A  )  7W14  (EM  2.20A  ) 
DBSNP rs34727960 
Subcellular location [CC][Isoform 1]: Cell membrane {ECO:0000269|PubMed:15533241};
Single-pass type I membrane protein {ECO:0000255}. Basolateral cell membrane {ECO:0000269|PubMed:11316797, ECO:0000269|PubMed:12021372, ECO:0000269|PubMed:12297051, ECO:0000269|PubMed:15364909};
Single-pass type I membrane protein {ECO:0000255}. Cell junction, tight junction {ECO:0000269|PubMed:11734628, ECO:0000269|PubMed:12297051}. Cell junction, adherens junction {ECO:0000269|PubMed:12297051}. Note=In epithelial cells localizes to the apical junction complex composed of tight and adherens junctions (PubMed:12297051). In airway epithelial cells localized to basolateral membrane but not to apical surface (PubMed:11316797). {ECO:0000269|PubMed:11316797, ECO:0000269|PubMed:12297051}.;
[Isoform 3]: Secreted {ECO:0000269|PubMed:14978041}.;
[Isoform 4]: Secreted {ECO:0000269|PubMed:14978041}.;
[Isoform 5]: Secreted {ECO:0000269|PubMed:14978041}.
Mouse PG classificationNA
click here to return to the previous page