Gene Information
Gene NameCWC22
OrganismHomo sapiens (Human)
Gene Length908
Protein NamesPre-mRNA-splicing factor CWC22 homolog (Nucampholin homolog) (fSAPb)
Target NameNA
Target TypeNA
Gene Age1292 ( ENSG00000163510 )
Evolutionary StageEukaryota
AlphaFoldDBQ9HCG8
Gene CardCWC22
Uniprot IDQ9HCG8
PfamPF02847
In ASDno
Allosteric Predictionno (-0.901639023)
Ortholog in AnimalsAlpaca_ CWC22 ( ortholog_one2one )
Dog_ CWC22 ( ortholog_one2one )
Macaque_ CWC22 ( ortholog_one2one )
Mouse_ Gm13691 ( ortholog_one2many )
Mouse_ Gm13694 ( ortholog_one2many )
Mouse_ Gm13697 ( ortholog_one2many )
Mouse_ Cwc22 ( ortholog_one2many )
Mouse_ Gm13693 ( ortholog_one2many )
Mouse_ Gm13698 ( ortholog_one2many )
Mouse_ Gm13695 ( ortholog_one2many )
Mouse_ Gm13696 ( ortholog_one2many )
Pig_ CWC22 ( ortholog_one2one )
Rat_ Cwc22 ( ortholog_one2one )
Rabbit_ CWC22 ( ortholog_one2one )
OhnologsNA
ParalogsNOM1
TissueNA
Tissue SpecificityNA
Pharmacological Animal ModelsNULL(Chimpanzee);NULL(Mouse);NULL(Rat);0.160575(Rabbit)
Gene Ontology
(biological process)
Gene Ontology
(cellular component)
Gene Ontology
(molecular function)
PDB 4C9B  (X-ray  2.00A  )  5MQF  (EM  5.90A  )  5XJC  (EM  3.60A  )  5YZG  (EM  4.10A  )  5Z56  (EM  5.10A  )  5Z57  (EM  6.50A  )  5Z58  (EM  4.90A  )  6FF7  (EM  4.50A  )  6ICZ  (EM  3.00A  )  6QDV  (EM  3.30A  )  6YVH  (X-ray  3.19A  )  6ZYM  (EM  3.40A  )  7A5P  (EM  5.00A  )  7DVQ  (EM  2.89A  )  7W59  (EM  3.60A  )  7W5A  (EM  3.60A  )  7W5B  (EM  4.30A  ) 
DBSNP rs17778270  rs11903115  rs1046356 
Subcellular location [CC]Nucleus {ECO:0000269|PubMed:11991638, ECO:0000269|PubMed:28502770, ECO:0000269|PubMed:29301961, ECO:0000269|PubMed:29360106}. Nucleus speckle {ECO:0000269|PubMed:22961380}. Note=Concentrates around speckles, which are sites of pre-mRNA synthesis and processing, where it colocalizes with EJC core proteins. {ECO:0000269|PubMed:22961380}.
Mouse PG classificationNA
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