| Gene Information | |
|---|---|
| Gene Name | CUL7 |
| Organism | Homo sapiens (Human) |
| Gene Length | 1698 |
| Protein Names | Cullin-7 (CUL-7) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 680 ( ENSG00000044090 ) |
| Evolutionary Stage | Vertebrata |
| AlphaFoldDB | Q14999 |
| Gene Card | CUL7 |
| Uniprot ID | Q14999 |
| Pfam | PF03256; PF11515; PF00888 |
| In ASD | no |
| Allosteric Prediction | no (-0.520065694) |
| Ortholog in Animals | Alpaca_ CUL7 ( ortholog_one2one ) Dog_ CUL7 ( ortholog_one2one ) GuineaPig_ CUL7 ( ortholog_one2one ) Macaque_ CUL7 ( ortholog_one2one ) Mouse_ Cul7 ( ortholog_one2one ) Pig_ CUL7 ( ortholog_one2one ) Rat_ Cul7 ( ortholog_one2one ) Rabbit_ CUL7 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | CUL9 |
| Tissue | NA |
| Tissue Specificity | Highly expressed in fetal kidney and adult skeletal muscle. Also abundant in fetal brain, as well as in adult pancreas, kidney, placenta and heart. Detected in trophoblasts, lymphoblasts, osteoblasts, chondrocytes and skin fibroblasts. {ECO:0000269|PubMed:16142236}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
|
| PDB | 2JNG (NMR - ) 7Z8B (EM 2.80A ) |
| DBSNP | rs7774330 rs9381231 rs34574340 rs61752334 rs36071170 rs121918229 rs759300846 |
| Subcellular location [CC] | Cytoplasm. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, perinuclear region. Golgi apparatus. Note=Colocalizes with FBXW8 at the Golgi apparatus in neurons; localization to Golgi is mediated by OBSL1. During mitosis, localizes to the mitotic apparatus (PubMed:24793695). CCDC8 is required for centrosomal location (PubMed:24793695). {ECO:0000269|PubMed:24793695}. |
| Mouse PG classification | LPG |
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