| Gene Information | |
|---|---|
| Gene Name | MAGEA4 |
| Organism | Homo sapiens (Human) |
| Gene Length | 317 |
| Protein Names | Melanoma-associated antigen 4 (Cancer/testis antigen 1.4) (CT1.4) (MAGE-4 antigen) (MAGE-41 antigen) (MAGE-X2 antigen) |
| Target Name | melanoma-associated antigen 4 |
| Target Type | Clinical trial target |
| Gene Age | 1488 ( ENSG00000147381 ) |
| Evolutionary Stage | Mammalia |
| AlphaFoldDB | P43358 |
| Gene Card | MAGEA4 |
| Uniprot ID | P43358 |
| Pfam | PF01454; PF12440 |
| In ASD | no |
| Allosteric Prediction | no (-1.11620543) |
| Ortholog in Animals | Macaque_ MAGEA4 ( ortholog_one2one ) Mouse_ Magea13 ( ortholog_many2many ) Rat_ Magea13 ( ortholog_many2many ) |
| Ohnologs | NA |
| Paralogs | MAGED4, MAGED4B, MAGEB17, MAGEB1, MAGEA3, MAGEA6, MAGEL2, MAGEA2, MAGEA2B, MAGEA12, NDN, MAGEB6, MAGEB6B, MAGEB2, MAGEH1, MAGEA8, MAGEE2, MAGEA11, MAGEB5, MAGED1, MAGEB10, MAGEA10, TRO, MAGEB4, MAGEC3, MAGEE1, MAGEA9, MAGEA9B, MAGEB3, MAGEC1, MAGEC2, NSMCE3, MAGEA1, MAGEB18, MAGEB16, MAGEF1, MAGED2 |
| Tissue | testis |
| Tissue Specificity | Expressed in many tumors of several types, such as melanoma, head and neck squamous cell carcinoma, lung carcinoma and breast carcinoma, but not in normal tissues except for testes and placenta. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 1I4F (X-ray 1.40A ) 2WA0 (X-ray 2.30A ) 6TRN (X-ray 1.35A ) 6TRO (X-ray 3.00A ) |
| DBSNP | rs1224431639 rs1047251 rs773875619 |
| Subcellular location [CC] | NA |
| Mouse PG classification | NA |
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