| Gene Information | |
|---|---|
| Gene Name | CTTN |
| Organism | Homo sapiens (Human) |
| Gene Length | 550 |
| Protein Names | Src substrate cortactin (Amplaxin) (Oncogene EMS1) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 645 ( ENSG00000085733 ) 3 ( ENSG00000288401 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | Q14247 |
| Gene Card | CTTN |
| Uniprot ID | Q14247 |
| Pfam | PF02218; PF14604 |
| In ASD | no |
| Allosteric Prediction | yes (1.002782306) |
| Ortholog in Animals | Dog_ CTTN ( ortholog_one2one ) GuineaPig_ CTTN ( ortholog_one2one ) Macaque_ CTTN ( ortholog_one2one ) Mouse_ Cttn ( ortholog_one2one ) Pig_ CTTN ( ortholog_one2one ) Rat_ Cttn ( ortholog_one2one ) Rabbit_ CTTN ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | HCLS1, COTL1, DBNL, DBN1 |
| Tissue | NA |
| Tissue Specificity | NA |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 1X69 (NMR - ) 2D1X (X-ray 1.90A ) |
| DBSNP | NA |
| Subcellular location [CC] | Cytoplasm, cytoskeleton {ECO:0000269|PubMed:12151401}. Cell projection, lamellipodium {ECO:0000269|PubMed:12151401, ECO:0000269|PubMed:24574519}. Cell projection, ruffle. Cell projection, dendrite {ECO:0000250}. Cell projection {ECO:0000250|UniProtKB:Q66HL2}. Cell membrane {ECO:0000305|PubMed:17959782}; Peripheral membrane protein {ECO:0000305}; Cytoplasmic side {ECO:0000305}. Cell projection, podosome {ECO:0000250|UniProtKB:Q01406}. Cell junction {ECO:0000250|UniProtKB:Q66HL2}. Cell junction, focal adhesion {ECO:0000250|UniProtKB:Q66HL2}. Membrane, clathrin-coated pit {ECO:0000250|UniProtKB:Q66HL2}. Cell projection, dendritic spine {ECO:0000250}. Cytoplasm, cell cortex {ECO:0000269|PubMed:12151401}. Endoplasmic reticulum {ECO:0000250|UniProtKB:Q01406}. Note=Colocalizes transiently with PTK2/FAK1 at focal adhesions (By similarity). Associated with membrane ruffles and lamellipodia. In the presence of CTTNBP2NL, colocalizes with stress fibers (By similarity). In the presence of CTTNBP2, localizes at the cell cortex (By similarity). In response to neuronal activation by glutamate, redistributes from dendritic spines to the dendritic shaft (By similarity). Colocalizes with DNM2 at the basis of filopodia in hippocampus neuron growth zones (By similarity). {ECO:0000250|UniProtKB:Q60598, ECO:0000250|UniProtKB:Q66HL2}. |
| Mouse PG classification | NA |
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