| Gene Information | |
|---|---|
| Gene Name | CTSS |
| Organism | Homo sapiens (Human) |
| Gene Length | 331 |
| Protein Names | Cathepsin S (EC 3.4.22.27) |
| Target Name | cathepsin s |
| Target Type | Clinical trial target |
| Gene Age | 454 ( ENSG00000163131 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | P25774 |
| Gene Card | CTSS |
| Uniprot ID | P25774 |
| Pfam | PF08246; PF00112 |
| In ASD | no |
| Allosteric Prediction | yes (0.081297132) |
| Ortholog in Animals | Alpaca_ CTSS ( ortholog_one2one ) Dog_ CTSS ( ortholog_one2one ) GuineaPig_ CTSS ( ortholog_one2one ) Macaque_ CTSS ( ortholog_one2one ) Mouse_ Ctss ( ortholog_one2one ) Pig_ CTSS ( ortholog_one2one ) Rat_ Ctss ( ortholog_one2one ) Rabbit_ CTSS ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | CTSL, CTSV, CTSK, CTSH, TINAGL1, CTSO, CTSW, CTSF, TINAG, CTSB, CTSC, CTSZ |
| Tissue | NA |
| Tissue Specificity | NA |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
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| PDB | 1GLO (X-ray 2.20A ) 1MS6 (X-ray 1.90A ) 1NPZ (X-ray 2.00A ) 1NQC (X-ray 1.80A ) 2C0Y (X-ray 2.10A ) 2F1G (X-ray 1.90A ) 2FQ9 (X-ray 1.65A ) 2FRA (X-ray 1.90A ) 2FRQ (X-ray 1.60A ) 2FT2 (X-ray 1.70A ) 2FUD (X-ray 1.95A ) 2FYE (X-ray 2.20A ) 2G6D (X-ray 2.50A ) 2G7Y (X-ray 2.00A ) 2H7J (X-ray 1.50A ) 2HH5 (X-ray 1.80A ) 2HHN (X-ray 1.55A ) 2HXZ (X-ray 1.90A ) 2OP3 (X-ray 1.60A ) 2R9M (X-ray 1.97A ) 2R9N (X-ray 2.00A ) 2R9O (X-ray 2.00A ) 3IEJ (X-ray 2.18A ) 3N3G (X-ray 1.60A ) 3N4C (X-ray 1.90A ) 3OVX (X-ray 1.49A ) 4P6E (X-ray 1.80A ) 4P6G (X-ray 1.58A ) 5QBU (X-ray 2.78A ) 5QBV (X-ray 1.80A ) 5QBW (X-ray 3.01A ) 5QBX (X-ray 2.10A ) 5QBY (X-ray 2.25A ) 5QBZ (X-ray 2.80A ) 5QC0 (X-ray 1.90A ) 5QC1 (X-ray 2.08A ) 5QC2 (X-ray 2.26A ) 5QC3 (X-ray 2.00A ) 5QC4 (X-ray 2.00A ) 5QC5 (X-ray 2.40A ) 5QC6 (X-ray 2.10A ) 5QC7 (X-ray 1.90A ) 5QC8 (X-ray 1.74A ) 5QC9 (X-ray 2.00A ) 5QCA (X-ray 2.29A ) 5QCB (X-ray 2.20A ) 5QCC (X-ray 1.80A ) 5QCD (X-ray 1.95A ) 5QCE (X-ray 2.78A ) 5QCF (X-ray 2.10A ) 5QCG (X-ray 2.69A ) 5QCH (X-ray 2.20A ) 5QCI (X-ray 2.18A ) 5QCJ (X-ray 2.00A ) 6YYN (X-ray 2.22A ) 6YYO (X-ray 1.50A ) 6YYP (X-ray 2.05A ) 6YYQ (X-ray 2.51A ) 6YYR (X-ray 1.30A ) |
| DBSNP | rs2230061 rs1059604 |
| Subcellular location [CC] | Lysosome {ECO:0000269|PubMed:1377692}. Secreted {ECO:0000269|PubMed:9524075}. Cytoplasmic vesicle, phagosome {ECO:0000269|PubMed:30612035}. |
| Mouse PG classification | NA |
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