| Gene Information | |
|---|---|
| Gene Name | CTSL |
| Organism | Homo sapiens (Human) |
| Gene Length | 333 |
| Protein Names | Procathepsin L (EC 3.4.22.15) (Cathepsin L1) (Major excreted protein) (MEP) [Cleaved into: Cathepsin L; Cathepsin L heavy chain; Cathepsin L light chain] |
| Target Name | cathepsin l |
| Target Type | Clinical trial target |
| Gene Age | >4290 ( ENSG00000135047 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | P07711 |
| Gene Card | CTSL |
| Uniprot ID | P07711 |
| Pfam | PF08246; PF00112 |
| In ASD | no |
| Allosteric Prediction | yes (0.537998211) |
| Ortholog in Animals | Alpaca_ CTSL ( ortholog_one2one ) Macaque_ CTSL ( ortholog_one2one ) Pig_ CTSL ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | CTSK, CTSH, TINAGL1, CTSO, CTSW, CTSF, TINAG, CTSB, CTSC, CTSZ, CTSS, CTSV |
| Tissue | NA |
| Tissue Specificity | NA |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 1CJL (X-ray 2.20A ) 1CS8 (X-ray 1.80A ) 1ICF (X-ray 2.00A ) 1MHW (X-ray 1.90A ) 2NQD (X-ray 1.75A ) 2VHS (X-ray 1.50A ) 2XU1 (X-ray 1.45A ) 2XU3 (X-ray 0.90A ) 2XU4 (X-ray 1.12A ) 2XU5 (X-ray 1.60A ) 2YJ2 (X-ray 1.15A ) 2YJ8 (X-ray 1.30A ) 2YJ9 (X-ray 1.35A ) 2YJB (X-ray 1.40A ) 2YJC (X-ray 1.14A ) 3BC3 (X-ray 2.20A ) 3H89 (X-ray 2.50A ) 3H8B (X-ray 1.80A ) 3H8C (X-ray 2.50A ) 3HHA (X-ray 1.27A ) 3HWN (X-ray 2.33A ) 3IV2 (X-ray 2.20A ) 3K24 (X-ray 2.50A ) 3KSE (X-ray 1.71A ) 3OF8 (X-ray 2.20A ) 3OF9 (X-ray 1.76A ) 4AXL (X-ray 1.92A ) 4AXM (X-ray 2.80A ) 5F02 (X-ray 1.43A ) 5I4H (X-ray 1.42A ) 5MAE (X-ray 1.00A ) 5MAJ (X-ray 1.00A ) 5MQY (X-ray 1.13A ) 6EZP (X-ray 1.37A ) 6EZX (X-ray 2.34A ) 6F06 (X-ray 2.02A ) 6JD0 (X-ray 1.80A ) 6JD8 (X-ray 1.46A ) |
| DBSNP | NA |
| Subcellular location [CC] | Lysosome {ECO:0000250|UniProtKB:P06797}. Apical cell membrane {ECO:0000250|UniProtKB:P06797}; Peripheral membrane protein {ECO:0000250|UniProtKB:P06797}; Extracellular side {ECO:0000250|UniProtKB:P06797}. Cytoplasmic vesicle, secretory vesicle, chromaffin granule {ECO:0000250|UniProtKB:P25975}. Secreted, extracellular space {ECO:0000250|UniProtKB:P06797}. Secreted {ECO:0000250|UniProtKB:P06797}. Note=Localizes to the apical membrane of thyroid epithelial cells. Released at extracellular space by activated dendritic cells and macrophages. {ECO:0000250|UniProtKB:P06797}.; [Isoform 2]: Nucleus {ECO:0000269|PubMed:15099520}. Note=Translation initiation at downstream start sites allows the synthesis of isoforms that are devoid of a signal peptide and do not transit through the endoplasmic reticulum to localize to the nucleus (PubMed:15099520). Nuclear location varies during the cell cycle, with higher levels during S phase (PubMed:15099520). {ECO:0000269|PubMed:15099520}. |
| Mouse PG classification | NA |
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