| Gene Information | |
|---|---|
| Gene Name | CTSK |
| Organism | Homo sapiens (Human) |
| Gene Length | 329 |
| Protein Names | Cathepsin K (EC 3.4.22.38) (Cathepsin O) (Cathepsin O2) (Cathepsin X) |
| Target Name | cathepsin k |
| Target Type | Clinical trial target |
| Gene Age | 454 ( ENSG00000143387 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | P43235 |
| Gene Card | CTSK |
| Uniprot ID | P43235 |
| Pfam | PF08246; PF00112 |
| In ASD | yes |
| Allosteric Prediction | yes (1.000063713) |
| Ortholog in Animals | Alpaca_ CTSK ( ortholog_one2one ) Dog_ CTSK ( ortholog_one2one ) GuineaPig_ CTSK ( ortholog_one2one ) Mouse_ Ctsk ( ortholog_one2one ) Pig_ CTSK ( ortholog_one2one ) Rat_ Ctsk ( ortholog_one2one ) Rabbit_ CTSK ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | CTSL, CTSV, CTSH, TINAGL1, CTSO, CTSW, CTSF, TINAG, CTSB, CTSC, CTSZ, CTSS |
| Tissue | NA |
| Tissue Specificity | Predominantly expressed in osteoclasts (bones) (PubMed:7805878). Expressed in thyroid epithelial cells (PubMed:11082042). {ECO:0000269|PubMed:11082042, ECO:0000269|PubMed:7805878}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | 1ATK (X-ray 2.20A ) 1AU0 (X-ray 2.60A ) 1AU2 (X-ray 2.60A ) 1AU3 (X-ray 2.50A ) 1AU4 (X-ray 2.30A ) 1AYU (X-ray 2.20A ) 1AYV (X-ray 2.30A ) 1AYW (X-ray 2.40A ) 1BGO (X-ray 2.30A ) 1BY8 (X-ray 2.60A ) 1MEM (X-ray 1.80A ) 1NL6 (X-ray 2.80A ) 1NLJ (X-ray 2.40A ) 1Q6K (X-ray 2.10A ) 1SNK (X-ray 2.40A ) 1TU6 (X-ray 1.75A ) 1U9V (X-ray 2.20A ) 1U9W (X-ray 2.30A ) 1U9X (X-ray 2.10A ) 1VSN (X-ray 2.00A ) 1YK7 (X-ray 2.50A ) 1YK8 (X-ray 2.60A ) 1YT7 (X-ray 2.30A ) 2ATO (X-ray 2.00A ) 2AUX (X-ray 2.40A ) 2AUZ (X-ray 2.30A ) 2BDL (X-ray 2.00A ) 2R6N (X-ray 1.95A ) 3C9E (X-ray 1.80A ) 3H7D (X-ray 2.24A ) 3KW9 (X-ray 1.80A ) 3KWB (X-ray 2.02A ) 3KWZ (X-ray 1.49A ) 3KX1 (X-ray 1.51A ) 3O0U (X-ray 1.80A ) 3O1G (X-ray 1.65A ) 3OVZ (X-ray 2.02A ) 4DMX (X-ray 1.70A ) 4DMY (X-ray 1.63A ) 4N79 (X-ray 2.62A ) 4N8W (X-ray 2.02A ) 4X6H (X-ray 1.00A ) 4X6I (X-ray 1.87A ) 4X6J (X-ray 1.59A ) 4YV8 (X-ray 2.00A ) 4YVA (X-ray 1.80A ) 5J94 (X-ray 2.60A ) 5JA7 (X-ray 1.61A ) 5JH3 (X-ray 1.75A ) 5TDI (X-ray 1.40A ) 5TUN (X-ray 1.62A ) 5Z5O (X-ray 1.92A ) 6ASH (X-ray 1.42A ) 6HGY (X-ray 2.20A ) 6PXF (X-ray 1.85A ) 6QBS (X-ray 1.70A ) 6QL8 (X-ray 1.80A ) 6QLM (X-ray 1.50A ) 6QLW (X-ray 2.00A ) 6QLX (X-ray 2.10A ) 6QM0 (X-ray 1.90A ) 7NXL (X-ray 1.80A ) 7NXM (X-ray 1.72A ) 7PCK (X-ray 3.20A ) 7QBL (X-ray 2.00A ) 7QBM (X-ray 1.88A ) 7QBN (X-ray 1.55A ) 7QBO (X-ray 1.90A ) |
| DBSNP | rs74315305 rs74315302 rs74315304 rs29001685 |
| Subcellular location [CC] | Lysosome {ECO:0000269|PubMed:11082042}. Secreted {ECO:0000269|PubMed:11082042}. Apical cell membrane {ECO:0000269|PubMed:11082042}; Peripheral membrane protein {ECO:0000269|PubMed:11082042}; Extracellular side {ECO:0000269|PubMed:11082042}. Note=Localizes to the lumen of thyroid follicles and to the apical membrane of thyroid epithelial cells. {ECO:0000269|PubMed:11082042}. |
| Mouse PG classification | HPG |
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