| Gene Information | |
|---|---|
| Gene Name | CTSC |
| Organism | Homo sapiens (Human) |
| Gene Length | 463 |
| Protein Names | Dipeptidyl peptidase 1 (EC 3.4.14.1) (Cathepsin C) (Cathepsin J) (Dipeptidyl peptidase I) (DPP-I) (DPPI) (Dipeptidyl transferase) [Cleaved into: Dipeptidyl peptidase 1 exclusion domain chain (Dipeptidyl peptidase I exclusion domain chain); Dipeptidyl peptidase 1 heavy chain (Dipeptidyl peptidase I heavy chain); Dipeptidyl peptidase 1 light chain (Dipeptidyl peptidase I light chain)] |
| Target Name | dipeptidyl peptidase i |
| Target Type | Clinical trial target |
| Gene Age | 1488 ( ENSG00000109861 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | P53634 |
| Gene Card | CTSC |
| Uniprot ID | P53634 |
| Pfam | PF08773; PF00112 |
| In ASD | yes |
| Allosteric Prediction | no (-0.197430367) |
| Ortholog in Animals | Alpaca_ CTSC ( ortholog_one2one ) Dog_ CTSC ( ortholog_one2many ) GuineaPig_ CTSC ( ortholog_one2one ) Macaque_ CTSC ( ortholog_one2one ) Mouse_ Ctsc ( ortholog_one2one ) Pig_ CTSC ( ortholog_one2one ) Rat_ Ctsc ( ortholog_one2one ) Rabbit_ CTSC ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | CTSL, CTSV, CTSK, CTSH, TINAGL1, CTSO, CTSW, CTSF, TINAG, CTSB, CTSZ, CTSS |
| Tissue | NA |
| Tissue Specificity | Ubiquitous. Highly expressed in lung, kidney and placenta. Detected at intermediate levels in colon, small intestine, spleen and pancreas. {ECO:0000269|PubMed:9092576}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
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| PDB | 1K3B (X-ray 2.15A ) 2DJF (X-ray 2.00A ) 2DJG (X-ray 2.05A ) 3PDF (X-ray 1.85A ) 4CDC (X-ray 2.40A ) 4CDD (X-ray 2.35A ) 4CDE (X-ray 2.40A ) 4CDF (X-ray 2.20A ) 4OEL (X-ray 1.40A ) 4OEM (X-ray 1.52A ) |
| DBSNP | rs104894210 rs104894216 rs760130711 rs749103588 rs217086 rs764724707 rs104894207 rs587777534 rs587777534 rs104894208 rs748729285 rs104894214 rs1484758757 rs1294233227 rs1044703733 rs104894211 rs200627023 rs151269219 rs28937571 rs104894215 rs3888798 |
| Subcellular location [CC] | Lysosome. |
| Mouse PG classification | LPG |
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