| Gene Information | |
|---|---|
| Gene Name | CTSB |
| Organism | Homo sapiens (Human) |
| Gene Length | 339 |
| Protein Names | Cathepsin B (EC 3.4.22.1) (APP secretase) (APPS) (Cathepsin B1) [Cleaved into: Cathepsin B light chain; Cathepsin B heavy chain] |
| Target Name | cathepsin b |
| Target Type | Preclinical target |
| Gene Age | 1488 ( ENSG00000164733 ) 3 ( ENSG00000285132 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | P07858 |
| Gene Card | CTSB |
| Uniprot ID | P07858 |
| Pfam | PF00112; PF08127 |
| In ASD | yes |
| Allosteric Prediction | yes (1.340789084) |
| Ortholog in Animals | Alpaca_ CTSB ( ortholog_one2one ) Dog_ CTSB ( ortholog_one2one ) GuineaPig_ CTSB ( ortholog_one2one ) Macaque_ CTSB ( ortholog_one2one ) Mouse_ Ctsb ( ortholog_one2one ) Pig_ CTSB ( ortholog_one2one ) Rat_ Ctsb ( ortholog_one2one ) Rabbit_ CTSB ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | CTSL, CTSV, CTSK, CTSH, TINAGL1, CTSO, CTSW, CTSF, TINAG, CTSC, CTSZ, CTSS |
| Tissue | NA |
| Tissue Specificity | Expressed in the stratum spinosum of the epidermis. Weak expression is detected in the stratum granulosum. {ECO:0000269|PubMed:28457472}. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);0.002240(Rat);NULL(Rabbit) |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | 1CSB (X-ray 2.00A ) 1GMY (X-ray 1.90A ) 1HUC (X-ray 2.10A ) 1PBH (X-ray 3.20A ) 2IPP (X-ray 2.15A ) 2PBH (X-ray 3.30A ) 3AI8 (X-ray 2.11A ) 3CBJ (X-ray 1.80A ) 3CBK (X-ray 2.67A ) 3K9M (X-ray 2.61A ) 3PBH (X-ray 2.50A ) 5MBL (X-ray 1.81A ) 5MBM (X-ray 2.76A ) 6AY2 (X-ray 1.60A ) |
| DBSNP | rs12338 rs1803250 rs11548596 rs17573 |
| Subcellular location [CC] | Lysosome {ECO:0000269|PubMed:16733801}. Melanosome {ECO:0000269|PubMed:17081065}. Secreted, extracellular space {ECO:0000250|UniProtKB:A1E295}. Apical cell membrane {ECO:0000250|UniProtKB:P10605}; Peripheral membrane protein {ECO:0000250|UniProtKB:P10605}; Extracellular side {ECO:0000250|UniProtKB:P10605}. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV (PubMed:17081065). Localizes to the lumen of thyroid follicles and to the apical membrane of thyroid epithelial cells (By similarity). {ECO:0000250|UniProtKB:P10605, ECO:0000269|PubMed:17081065}. |
| Mouse PG classification | NA |
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