| Gene Information | |
|---|---|
| Gene Name | CTSA |
| Organism | Homo sapiens (Human) |
| Gene Length | 480 |
| Protein Names | Lysosomal protective protein (EC 3.4.16.5) (Carboxypeptidase C) (Carboxypeptidase L) (Cathepsin A) (Protective protein cathepsin A) (PPCA) (Protective protein for beta-galactosidase) [Cleaved into: Lysosomal protective protein 32 kDa chain; Lysosomal protective protein 20 kDa chain] |
| Target Name | cathepsin a |
| Target Type | Clinical trial target |
| Gene Age | 1714 ( ENSG00000064601 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | P10619 |
| Gene Card | CTSA |
| Uniprot ID | P10619 |
| Pfam | PF00450 |
| In ASD | no |
| Allosteric Prediction | yes (0.159983981) |
| Ortholog in Animals | Alpaca_ CTSA ( ortholog_one2one ) Dog_ CTSA ( ortholog_one2one ) GuineaPig_ CTSA ( ortholog_one2one ) Macaque_ CTSA ( ortholog_one2one ) Mouse_ Ctsa ( ortholog_one2one ) Pig_ CTSA ( ortholog_one2one ) Rat_ Ctsa ( ortholog_one2one ) Rabbit_ CTSA ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | CPVL, SCPEP1 |
| Tissue | NA |
| Tissue Specificity | NA |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 1IVY (X-ray 2.20A ) 3BP4 (X-ray 1.85A ) 3BP7 (X-ray 1.80A ) 3BXN (X-ray 1.86A ) 4AZ0 (X-ray 2.17A ) 4AZ3 (X-ray 2.04A ) 4CI9 (X-ray 1.58A ) 4CIA (X-ray 1.98A ) 4CIB (X-ray 1.89A ) 4MWS (X-ray 2.80A ) 4MWT (X-ray 3.85A ) 6WIA (X-ray 2.21A ) |
| DBSNP | rs137854541 rs538562022 rs28934603 rs137854542 rs137854545 rs137854546 rs137854544 rs137854543 rs137854548 rs137854547 rs137854540 rs137854549 |
| Subcellular location [CC] | Lysosome. |
| Mouse PG classification | NA |
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