| Gene Information | |
|---|---|
| Gene Name | KRT5 |
| Organism | Homo sapiens (Human) |
| Gene Length | 590 |
| Protein Names | Keratin, type II cytoskeletal 5 (58 kDa cytokeratin) (Cytokeratin-5) (CK-5) (Keratin-5) (K5) (Type-II keratin Kb5) |
| Target Name | keratin, type ii cytoskeletal 5 |
| Target Type | NA |
| Gene Age | 382 ( ENSG00000186081 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | P13647 |
| Gene Card | KRT5 |
| Uniprot ID | P13647 |
| Pfam | PF00038; PF16208 |
| In ASD | no |
| Allosteric Prediction | no (-0.367514519) |
| Ortholog in Animals | Alpaca_ KRT5 ( ortholog_one2one ) Alpaca_ KRT6A ( ortholog_one2one ) GuineaPig_ KRT5 ( ortholog_one2one ) Macaque_ KRT5 ( ortholog_one2one ) Mouse_ Krt5 ( ortholog_one2many ) Mouse_ Gm5478 ( ortholog_one2many ) Pig_ KRT5 ( ortholog_one2one ) Rat_ Krt5 ( ortholog_one2one ) Rabbit_ KRT5 ( ortholog_one2one ) |
| Ohnologs | KRT33A, GFAP, KRT19, KRT15, KRT10, KRT17P2, KRT16, KRT14, VIM, DES |
| Paralogs | VIM, KRT12, KRT74, INA, NEFM, KRT39, SYNM, KRT13, KRT80, KRT33B, KRT31, KRT77, KRT26, KRT32, KRT73, KRT28, KRT37, KRT38, KRT6B, KRT6A, KRT6C, KRT72, KRT20, KRT222, LMNB1, PRPH, KRT23, KRT4, KRT36, KRT7, KRT34, KRT75, KRT25, KRT76, KRT35, KRT78, KRT24, KRT40, KRT86, KRT83, KRT81, NES, DES, KRT2, KRT9, KRT27, KRT3, KRT84, LMNB2, KRT33A, KRT82, BFSP2, KRT14, KRT16, KRT85, LMNA, KRT8, GFAP, KRT17, KRT79, KRT71, KRT1, KRT19, LMNTD1, NEFL, KRT15, KRT18, KRT10 |
| Tissue | esophagus, skin, tongue, esophagus.mucosa, lower.leg.skin, suprapubic.skin, vagina |
| Tissue Specificity | Expressed in corneal epithelium (at protein level) (PubMed:26758872). Expressed in keratinocytes (at protein level) (PubMed:20128788, PubMed:31302245). {ECO:0000269|PubMed:20128788, ECO:0000269|PubMed:26758872, ECO:0000269|PubMed:31302245}. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);0.001000(Rat);0.033333(Rabbit) |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | 3TNU (X-ray 3.00A ) 6JFV (X-ray 2.60A ) |
| DBSNP | rs57499817 rs1065115 rs11170164 rs59851104 rs59851104 rs62635291 rs267607450 rs60617604 rs763608512 rs61222761 rs58058996 rs267607456 rs57378129 rs58619430 rs60720877 rs59115483 rs58163069 rs57890479 rs59092197 rs61495052 rs57781042 rs58480900 rs267607451 rs60715293 rs267607443 rs267607661 rs267607457 rs121912475 rs121912475 rs267607452 rs58976397 rs57751134 rs60586163 rs641615 rs58766676 rs58766676 rs200333163 rs59864957 rs1938635857 rs59840738 rs59335325 rs58107458 rs58072617 rs58072617 rs59464425 rs57142010 rs56790237 rs57142010 rs59730172 rs61297109 rs56729325 rs59112594 rs2669875 rs60809982 rs121912476 rs267607458 rs57845028 rs267607453 rs57599352 rs62642056 rs60062350 rs60271599 rs60596287 rs895084041 rs61348633 rs57155193 rs56922686 rs58319159 rs59190510 rs267607438 rs58608695 rs11549950 rs11549949 |
| Subcellular location [CC] | Cytoplasm {ECO:0000269|PubMed:20128788}. |
| Mouse PG classification | HPG |
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