| Gene Information | |
|---|---|
| Gene Name | CTPS1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 591 |
| Protein Names | CTP synthase 1 (EC 6.3.4.2) (CTP synthetase 1) (UTP--ammonia ligase 1) |
| Target Name | ctp synthase |
| Target Type | Clinical trial target |
| Gene Age | >4290 ( ENSG00000171793 ) |
| Evolutionary Stage | Cellular_organisms |
| AlphaFoldDB | P17812 |
| Gene Card | CTPS1 |
| Uniprot ID | P17812 |
| Pfam | PF06418; PF00117 |
| In ASD | no |
| Allosteric Prediction | yes (0.517765407) |
| Ortholog in Animals | Alpaca_ CTPS1 ( ortholog_one2one ) Dog_ CTPS1 ( ortholog_one2one ) GuineaPig_ CTPS1 ( ortholog_one2one ) Macaque_ CTPS1 ( ortholog_one2one ) Mouse_ Ctps ( ortholog_one2one ) Pig_ CTPS1 ( ortholog_one2one ) Rat_ Ctps1 ( ortholog_one2one ) Rabbit_ CTPS1 ( ortholog_one2one ) |
| Ohnologs | CTPS2 |
| Paralogs | CTPS2 |
| Tissue | NA |
| Tissue Specificity | Widely expressed. {ECO:0000269|PubMed:24870241}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 2VO1 (X-ray 2.80A ) 5U03 (EM 6.10A ) 7MGZ (EM 2.80A ) 7MH0 (EM 6.20A ) 7MIF (EM 3.10A ) 7MIG (EM 2.90A ) |
| DBSNP | rs17856308 |
| Subcellular location [CC] | Cytoplasm, cytosol {ECO:0000269|PubMed:25223282}. Note=Mainly cytosolic but when active detected in long filamentous structures (PubMed:25223282). Co-localizes with TNK2 in the cytosolic filaments (By similarity). {ECO:0000250|UniProtKB:P70698, ECO:0000269|PubMed:25223282}. |
| Mouse PG classification | NA |
| click here to return to the previous page | |