| Gene Information | |
|---|---|
| Gene Name | PLEKHF1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 279 |
| Protein Names | Pleckstrin homology domain-containing family F member 1 (PH domain-containing family F member 1) (Lysosome-associated apoptosis-inducing protein containing PH and FYVE domains) (Apoptosis-inducing protein) (PH and FYVE domain-containing protein 1) (Phafin-1) (Zinc finger FYVE domain-containing protein 15) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 1292 ( ENSG00000166289 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | Q96S99 |
| Gene Card | PLEKHF1 |
| Uniprot ID | Q96S99 |
| Pfam | PF01363; PF00169 |
| In ASD | no |
| Allosteric Prediction | no (-1.662013223) |
| Ortholog in Animals | Alpaca_ PLEKHF1 ( ortholog_one2one ) Dog_ PLEKHF1 ( ortholog_one2one ) GuineaPig_ PLEKHF1 ( ortholog_one2one ) Macaque_ PLEKHF1 ( ortholog_one2one ) Mouse_ Plekhf1 ( ortholog_one2one ) Pig_ PLEKHF1 ( ortholog_one2one ) Rat_ Plekhf1 ( ortholog_one2one ) |
| Ohnologs | PLEKHF2 |
| Paralogs | RUFY1, ZFYVE1, ZFYVE26, ZFYVE28, RUNDC3B, RUFY2, PLEKHM2, RUFY3, RUNDC3A, ZFYVE16, PLEKHF2, SNX29, ZFYVE19 |
| Tissue | NA |
| Tissue Specificity | Highly expressed in heart and skeletal muscle. Weakly expressed in brain, thymus, spleen, kidney, liver, small intestine, placenta and lung. {ECO:0000269|PubMed:16188880}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | NA |
| Subcellular location [CC] | Nucleus {ECO:0000269|PubMed:16188880}. Cytoplasm, perinuclear region {ECO:0000269|PubMed:16188880}. Lysosome {ECO:0000269|PubMed:16188880}. Note=Translocates to lysosome during apoptosis. |
| Mouse PG classification | NA |
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