| Gene Information | |
|---|---|
| Gene Name | MGMT |
| Organism | Homo sapiens (Human) |
| Gene Length | 207 |
| Protein Names | Methylated-DNA--protein-cysteine methyltransferase (EC 2.1.1.63) (6-O-methylguanine-DNA methyltransferase) (MGMT) (O-6-methylguanine-DNA-alkyltransferase) |
| Target Name | methylated-dna--protein-cysteine methyltransferase |
| Target Type | NA |
| Gene Age | 987 ( ENSG00000170430 ) |
| Evolutionary Stage | Cellular_organisms |
| AlphaFoldDB | P16455 |
| Gene Card | MGMT |
| Uniprot ID | P16455 |
| Pfam | PF01035; PF02870 |
| In ASD | no |
| Allosteric Prediction | yes (1.177134024) |
| Ortholog in Animals | Alpaca_ MGMT ( ortholog_one2one ) Dog_ MGMT ( ortholog_one2one ) GuineaPig_ MGMT ( ortholog_one2one ) Macaque_ MGMT ( ortholog_one2one ) Mouse_ Mgmt ( ortholog_one2one ) Pig_ MGMT ( ortholog_one2one ) Rat_ Mgmt ( ortholog_one2one ) Rabbit_ MGMT ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | NA |
| Tissue Specificity | NA |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 1EH6 (X-ray 2.00A ) 1EH7 (X-ray 2.00A ) 1EH8 (X-ray 2.50A ) 1QNT (X-ray 1.90A ) 1T38 (X-ray 3.20A ) 1T39 (X-ray 3.30A ) 1YFH (X-ray 3.01A ) |
| DBSNP | rs2020893 rs12917 rs2308322 rs2282164 rs12917 rs2308321 rs2308321 rs2308318 rs2308320 rs2308327 |
| Subcellular location [CC] | Nucleus. |
| Mouse PG classification | NA |
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