Gene Information | |
---|---|
Gene Name | KCNJ1 |
Organism | Homo sapiens (Human) |
Gene Length | 391 |
Protein Names | ATP-sensitive inward rectifier potassium channel 1 (ATP-regulated potassium channel ROM-K) (Inward rectifier K(+) channel Kir1.1) (Potassium channel, inwardly rectifying subfamily J member 1) |
Target Name | inward rectifier potassium channel kir1.1 |
Target Type | Patented-recorded target |
Gene Age | 645 ( ENSG00000151704 ) |
Evolutionary Stage | Euk+Bac |
AlphaFoldDB | P48048 |
Gene Card | KCNJ1 |
Uniprot ID | P48048 |
Pfam | PF01007; PF17655 |
In ASD | no |
Allosteric Prediction | yes (1.25532575) |
Ortholog in Animals | Alpaca_ KCNJ1 ( ortholog_one2one ) Dog_ KCNJ1 ( ortholog_one2one ) GuineaPig_ KCNJ1 ( ortholog_one2one ) Macaque_ KCNJ1 ( ortholog_one2one ) Mouse_ Kcnj1 ( ortholog_one2one ) Pig_ KCNJ1 ( ortholog_one2one ) Rat_ Kcnj1 ( ortholog_one2one ) Rabbit_ KCNJ1 ( ortholog_one2one ) |
Ohnologs | NA |
Paralogs | KCNJ15, KCNJ10, KCNJ13, KCNJ11, KCNJ8, KCNJ14, KCNJ18, KCNJ4, KCNJ16, KCNJ12, KCNJ2, KCNJ9, KCNJ3, KCNJ5, KCNJ6 |
Tissue | kidney, cortex.of.kidney |
Tissue Specificity | In the kidney and pancreatic islets. Lower levels in skeletal muscle, pancreas, spleen, brain, heart and liver. {ECO:0000269|PubMed:7635463}. |
Pharmacological Animal Models | NA |
Gene Ontology (biological process) |
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Gene Ontology (cellular component) |
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Gene Ontology (molecular function) |
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PDB | NA |
DBSNP | rs34191956 rs1213764655 rs104894250 rs373745258 rs766131330 rs104894251 rs104894254 rs104894253 rs104894246 rs104894245 rs753949204 rs59172778 |
Subcellular location [CC] | Cell membrane {ECO:0000269|PubMed:12684516}; Multi-pass membrane protein {ECO:0000269|PubMed:12684516}. Note=Phosphorylation at Ser-44 by SGK1 is necessary for its expression at the cell membrane. {ECO:0000269|PubMed:12684516}. |
Mouse PG classification | NA |
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