Gene Information
Gene NameKCNJ1
OrganismHomo sapiens (Human)
Gene Length391
Protein NamesATP-sensitive inward rectifier potassium channel 1 (ATP-regulated potassium channel ROM-K) (Inward rectifier K(+) channel Kir1.1) (Potassium channel, inwardly rectifying subfamily J member 1)
Target Nameinward rectifier potassium channel kir1.1
Target TypePatented-recorded target
Gene Age645 ( ENSG00000151704 )
Evolutionary StageEuk+Bac
AlphaFoldDBP48048
Gene CardKCNJ1
Uniprot IDP48048
PfamPF01007; PF17655
In ASDno
Allosteric Predictionyes (1.25532575)
Ortholog in AnimalsAlpaca_ KCNJ1 ( ortholog_one2one )
Dog_ KCNJ1 ( ortholog_one2one )
GuineaPig_ KCNJ1 ( ortholog_one2one )
Macaque_ KCNJ1 ( ortholog_one2one )
Mouse_ Kcnj1 ( ortholog_one2one )
Pig_ KCNJ1 ( ortholog_one2one )
Rat_ Kcnj1 ( ortholog_one2one )
Rabbit_ KCNJ1 ( ortholog_one2one )
OhnologsNA
ParalogsKCNJ15, KCNJ10, KCNJ13, KCNJ11, KCNJ8, KCNJ14, KCNJ18, KCNJ4, KCNJ16, KCNJ12, KCNJ2, KCNJ9, KCNJ3, KCNJ5, KCNJ6
Tissuekidney, cortex.of.kidney
Tissue SpecificityIn the kidney and pancreatic islets. Lower levels in skeletal muscle, pancreas, spleen, brain, heart and liver. {ECO:0000269|PubMed:7635463}.
Pharmacological Animal ModelsNA
Gene Ontology
(biological process)
Gene Ontology
(cellular component)
Gene Ontology
(molecular function)
PDB NA 
DBSNP rs34191956  rs1213764655  rs104894250  rs373745258  rs766131330  rs104894251  rs104894254  rs104894253  rs104894246  rs104894245  rs753949204  rs59172778 
Subcellular location [CC]Cell membrane {ECO:0000269|PubMed:12684516};
Multi-pass membrane protein {ECO:0000269|PubMed:12684516}. Note=Phosphorylation at Ser-44 by SGK1 is necessary for its expression at the cell membrane. {ECO:0000269|PubMed:12684516}.
Mouse PG classificationNA
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