| Gene Information | |
|---|---|
| Gene Name | PIK3CB |
| Organism | Homo sapiens (Human) |
| Gene Length | 1070 |
| Protein Names | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform (PI3-kinase subunit beta) (PI3K-beta) (PI3Kbeta) (PtdIns-3-kinase subunit beta) (EC 2.7.1.153) (Phosphatidylinositol 4,5-bisphosphate 3-kinase 110 kDa catalytic subunit beta) (PtdIns-3-kinase subunit p110-beta) (p110beta) (Serine/threonine protein kinase PIK3CB) (EC 2.7.11.1) |
| Target Name | pi3-kinase beta |
| Target Type | Clinical trial target |
| Gene Age | 1064 ( ENSG00000051382 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | P42338 |
| Gene Card | PIK3CB |
| Uniprot ID | P42338 |
| Pfam | PF00454; PF00792; PF02192; PF00794; PF00613 |
| In ASD | no |
| Allosteric Prediction | yes (1.187469502) |
| Ortholog in Animals | Alpaca_ PIK3CB ( ortholog_one2one ) Dog_ PIK3CB ( ortholog_one2one ) GuineaPig_ PIK3CB ( ortholog_one2one ) Macaque_ PIK3CB ( ortholog_one2one ) Mouse_ Pik3cb ( ortholog_one2one ) Pig_ PIK3CB ( ortholog_one2one ) Rat_ Pik3cb ( ortholog_one2one ) Rabbit_ PIK3CB ( ortholog_one2one ) |
| Ohnologs | PIK3CG, PIK3CA, PIK3CD |
| Paralogs | PIK3CG, PIK3C2B, PIK3C2A, PI4KB, PIK3CA, PI4KA, PIK3C2G, PIK3C3, PIK3CD |
| Tissue | NA |
| Tissue Specificity | Expressed ubiquitously. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);0.003717(Rat);0.030769(Rabbit) |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | rs2230462 |
| Subcellular location [CC] | Cytoplasm {ECO:0000269|PubMed:21383062}. Nucleus {ECO:0000269|PubMed:21383062}. Note=Interaction with PIK3R2 is required for nuclear localization and export. |
| Mouse PG classification | NA |
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