| Gene Information | |
|---|---|
| Gene Name | CSF3R |
| Organism | Homo sapiens (Human) |
| Gene Length | 836 |
| Protein Names | Granulocyte colony-stimulating factor receptor (G-CSF receptor) (G-CSF-R) (CD antigen CD114) |
| Target Name | granulocyte colony-stimulating factor receptor |
| Target Type | NA |
| Gene Age | 454 ( ENSG00000119535 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | Q99062 |
| Gene Card | CSF3R |
| Uniprot ID | Q99062 |
| Pfam | PF00041; PF06328 |
| In ASD | no |
| Allosteric Prediction | yes (0.313600248) |
| Ortholog in Animals | Alpaca_ CSF3R ( ortholog_one2one ) Dog_ CSF3R ( ortholog_one2one ) GuineaPig_ CSF3R ( ortholog_one2one ) Macaque_ CSF3R ( ortholog_one2one ) Mouse_ Csf3r ( ortholog_one2one ) Pig_ CSF3R ( ortholog_one2one ) Rat_ Csf3r ( ortholog_one2one ) Rabbit_ CSF3R ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | CRLF1, IL13RA2, IL11RA, IL13RA1, CNTFR, IL2RG, CRLF2, IL31RA, IL3RA, IL6ST, IL12RB1, IL12RB2, GHR, CSF2RA, IL6R, IL27RA, IL23R, LIFR, OSMR, IL5RA, EBI3, PRLR, LEPR |
| Tissue | appendix, bone.marrow, spleen, whole.blood |
| Tissue Specificity | One or several isoforms have been found in myelogenous leukemia cell line KG-1, leukemia U-937 cell line, in bone marrow cells, placenta, and peripheral blood granulocytes. Isoform GCSFR-2 is found only in leukemia U-937 cells. Isoform GCSFR-3 is highly expressed in placenta. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 2D9Q (X-ray 2.80A ) |
| DBSNP | rs764202764 rs3917973 rs606231473 rs3918018 rs3917974 rs3918019 rs3918020 rs3917991 rs3917996 rs3917997 rs121918426 |
| Subcellular location [CC] | [Isoform 2]: Secreted {ECO:0000305}.; Cell membrane {ECO:0000269|PubMed:24753537}; Single-pass type I membrane protein {ECO:0000255}. |
| Mouse PG classification | NA |
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