| Gene Information | |
|---|---|
| Gene Name | TGFB3 |
| Organism | Homo sapiens (Human) |
| Gene Length | 412 |
| Protein Names | Transforming growth factor beta-3 proprotein [Cleaved into: Latency-associated peptide (LAP); Transforming growth factor beta-3 (TGF-beta-3)] |
| Target Name | transforming growth factor beta 3 |
| Target Type | Clinical trial target |
| Gene Age | 680 ( ENSG00000119699 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | P10600 |
| Gene Card | TGFB3 |
| Uniprot ID | P10600 |
| Pfam | PF00019; PF00688 |
| In ASD | no |
| Allosteric Prediction | yes (0.480167955) |
| Ortholog in Animals | Alpaca_ TGFB3 ( ortholog_one2one ) Dog_ TGFB3 ( ortholog_one2one ) GuineaPig_ TGFB3 ( ortholog_one2one ) Macaque_ TGFB3 ( ortholog_one2one ) Mouse_ Tgfb3 ( ortholog_one2one ) Pig_ TGFB3 ( ortholog_one2one ) Rat_ Tgfb3 ( ortholog_one2one ) Rabbit_ TGFB3 ( ortholog_one2one ) |
| Ohnologs | TGFB1, TGFB2 |
| Paralogs | BMP3, MSTN, INHBC, GDF15, BMP6, INHBA, GDF6, BMP2, BMP10, TGFB1, INHA, GDF9, GDF11, BMP5, BMP7, INHBB, GDF5, GDF1, GDF2, BMP4, LEFTY1, LEFTY2, GDF3, INHBE, GDF7, GDF10, BMP15, TGFB2, BMP8A, BMP8B, NODAL |
| Tissue | NA |
| Tissue Specificity | NA |
| Pharmacological Animal Models | 0.000730(Chimpanzee);0.001000(Mouse);0.004323(Rat);NULL(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 1KTZ (X-ray 2.15A ) 1TGJ (X-ray 2.00A ) 1TGK (X-ray 3.30A ) 2PJY (X-ray 3.00A ) 3EO1 (X-ray 3.10A ) 4UM9 (X-ray 2.50A ) |
| DBSNP | rs4252315 rs398122984 |
| Subcellular location [CC] | [Latency-associated peptide]: Secreted, extracellular space, extracellular matrix {ECO:0000250|UniProtKB:P01137}.; [Transforming growth factor beta-3]: Secreted {ECO:0000250|UniProtKB:P01137}. |
| Mouse PG classification | NA |
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