| Gene Information | |
|---|---|
| Gene Name | ACSL4 |
| Organism | Homo sapiens (Human) |
| Gene Length | 711 |
| Protein Names | Long-chain-fatty-acid--CoA ligase 4 (EC 6.2.1.3) (Arachidonate--CoA ligase) (EC 6.2.1.15) (Long-chain acyl-CoA synthetase 4) (LACS 4) |
| Target Name | long-chain-fatty-acid--coa ligase 4 |
| Target Type | NA |
| Gene Age | >4290 ( ENSG00000068366 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | O60488 |
| Gene Card | ACSL4 |
| Uniprot ID | O60488 |
| Pfam | PF00501 |
| In ASD | no |
| Allosteric Prediction | yes (0.91048575) |
| Ortholog in Animals | Alpaca_ ACSL4 ( ortholog_one2one ) Dog_ ACSL4 ( ortholog_one2one ) GuineaPig_ ACSL4 ( ortholog_one2one ) Macaque_ ACSL4 ( ortholog_one2one ) Mouse_ Acsl4 ( ortholog_one2one ) Pig_ ACSL4 ( ortholog_one2one ) Rat_ Acsl4 ( ortholog_one2one ) Rabbit_ ACSL4 ( ortholog_one2one ) |
| Ohnologs | ACSL3 |
| Paralogs | SLC27A4, ACSBG1, ACSL1, ACSL3, SLC27A3, ACSL6, ACSBG2, SLC27A6, ACSL5, SLC27A2, SLC27A1, SLC27A5 |
| Tissue | NA |
| Tissue Specificity | NA |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | rs753267653 rs122458138 |
| Subcellular location [CC] | Mitochondrion outer membrane {ECO:0000250}; Single-pass type III membrane protein {ECO:0000250}. Peroxisome membrane {ECO:0000250}; Single-pass type III membrane protein {ECO:0000250}. Microsome membrane {ECO:0000250}; Single-pass type III membrane protein {ECO:0000250}. Endoplasmic reticulum membrane {ECO:0000269|PubMed:24269233}; Single-pass type III membrane protein {ECO:0000250}. Cell membrane {ECO:0000269|PubMed:24269233}. |
| Mouse PG classification | NA |
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