| Gene Information | |
|---|---|
| Gene Name | CST6 |
| Organism | Homo sapiens (Human) |
| Gene Length | 149 |
| Protein Names | Cystatin-M (Cystatin-6) (Cystatin-E) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 332 ( ENSG00000175315 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | Q15828 |
| Gene Card | CST6 |
| Uniprot ID | Q15828 |
| Pfam | PF00031 |
| In ASD | no |
| Allosteric Prediction | no (-0.994588609) |
| Ortholog in Animals | Alpaca_ CST6 ( ortholog_one2one ) Dog_ CST6 ( ortholog_one2one ) GuineaPig_ CST6 ( ortholog_one2one ) Macaque_ CST6 ( ortholog_one2one ) Mouse_ Cst6 ( ortholog_one2one ) Pig_ CST6 ( ortholog_one2one ) Rat_ Cst6 ( ortholog_one2one ) |
| Ohnologs | CST3, CST4, CST5, CST2, CST1 |
| Paralogs | CST3, CST2, CST4, CST1, CST5, CST8, CST9, CST9L, CSTL1, CST11, CST7 |
| Tissue | skin, lower.leg.skin, suprapubic.skin |
| Tissue Specificity | Restricted to the stratum granulosum of normal skin, the stratum granulosum/spinosum of psoriatic skin, and the secretory coils of eccrine sweat glands. Low expression levels are found in the nasal cavity. {ECO:0000269|PubMed:11348457}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 4N6L (X-ray 1.95A ) 4N6M (X-ray 2.90A ) 4N6N (X-ray 1.87A ) 4N6O (X-ray 1.80A ) 6FK0 (X-ray 2.90A ) |
| DBSNP | NA |
| Subcellular location [CC] | Secreted. |
| Mouse PG classification | NA |
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