| Gene Information | |
|---|---|
| Gene Name | CST3 |
| Organism | Homo sapiens (Human) |
| Gene Length | 146 |
| Protein Names | Cystatin-C (Cystatin-3) (Gamma-trace) (Neuroendocrine basic polypeptide) (Post-gamma-globulin) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 544 ( ENSG00000101439 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | P01034 |
| Gene Card | CST3 |
| Uniprot ID | P01034 |
| Pfam | PF00031 |
| In ASD | no |
| Allosteric Prediction | yes (0.217893673) |
| Ortholog in Animals | Alpaca_ CST3 ( ortholog_one2one ) Macaque_ CST3 ( ortholog_one2one ) Mouse_ Cst3 ( ortholog_one2many ) Mouse_ Cst10 ( ortholog_one2many ) Pig_ CST3 ( ortholog_one2one ) Rat_ Cst5 ( ortholog_one2many ) Rat_ Cst3 ( ortholog_one2many ) Rat_ AABR07054232.1 ( ortholog_one2many ) Rat_ P22k15 ( ortholog_one2many ) Rat_ Cyss ( ortholog_one2many ) Rat_ Andpro ( ortholog_one2many ) |
| Ohnologs | CST6 |
| Paralogs | CST2, CST4, CST1, CST5, CST8, CST9, CST9L, CSTL1, CST11, CST6, CST7 |
| Tissue | NA |
| Tissue Specificity | Expressed in submandibular and sublingual saliva but not in parotid saliva (at protein level). Expressed in various body fluids, such as the cerebrospinal fluid and plasma. Expressed in highest levels in the epididymis, vas deferens, brain, thymus, and ovary and the lowest in the submandibular gland. {ECO:0000269|PubMed:15274116, ECO:0000269|PubMed:20189825}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 1G96 (X-ray 2.50A ) 1R4C (X-ray 2.18A ) 1TIJ (X-ray 3.03A ) 3GAX (X-ray 1.70A ) 3NX0 (X-ray 2.04A ) 3PS8 (X-ray 2.55A ) 3QRD (X-ray 2.19A ) 3S67 (X-ray 2.26A ) 3SVA (X-ray 3.02A ) 6ROA (X-ray 2.65A ) 6RPV (Other - ) |
| DBSNP | rs1064039 rs28939068 |
| Subcellular location [CC] | Secreted {ECO:0000269|PubMed:20189825}. |
| Mouse PG classification | NA |
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