Gene Information
Gene NameCSS2
OrganismHomo sapiens (Human)
Gene Length775
Protein NamesChondroitin sulfate synthase 2 (EC 2.4.1.175) (EC 2.4.1.226) (Chondroitin glucuronyltransferase 2) (Chondroitin-polymerizing factor) (ChPF) (Glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase II) (N-acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferase II) (N-acetylgalactosaminyltransferase 2)
Target NameNA
Target TypeNA
Gene AgeNA
Evolutionary StageNA
AlphaFoldDBQ8IZ52
Gene CardCHPF
Uniprot IDQ8IZ52
PfamPF05679
In ASDno
Allosteric PredictionNA
Ortholog in AnimalsNA
OhnologsNA
ParalogsNA
TissueNA
Tissue SpecificityUbiquitous. Highly expressed in pancreas, ovary, brain, heart, skeletal muscle, colon, kidney, liver, stomach, spleen and placenta. {ECO:0000269|PubMed:12716890, ECO:0000269|PubMed:12761225}.;
[Isoform 2]: Expressed in brain, spleen, ovary, testis, lung and peripheral mononuclear cells. {ECO:0000269|PubMed:22082830}.;
[Isoform 3]: Also ubiquitous. {ECO:0000269|PubMed:22082830}.
Pharmacological Animal ModelsNA
Gene Ontology
(biological process)
Gene Ontology
(cellular component)
Gene Ontology
(molecular function)
PDB NA 
DBSNP rs6436155 
Subcellular location [CC][Isoform 1]: Golgi apparatus, Golgi stack membrane {ECO:0000305};
Single-pass type II membrane protein {ECO:0000305}. Cytoplasm, cytosol {ECO:0000269|PubMed:22082830}.;
[Isoform 3]: Cytoplasm, cytosol {ECO:0000269|PubMed:22082830}. Mitochondrion {ECO:0000269|PubMed:22082830}.;
[Isoform 2]: Mitochondrion matrix {ECO:0000269|PubMed:22082830}.
Mouse PG classificationNA
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