Gene Information
Gene NameCSRP3
OrganismHomo sapiens (Human)
Gene Length194
Protein NamesCysteine and glycine-rich protein 3 (Cardiac LIM protein) (Cysteine-rich protein 3) (CRP3) (LIM domain protein, cardiac) (Muscle LIM protein)
Target NameNA
Target TypeNA
Gene Age544 ( ENSG00000129170 )
Evolutionary StageEukaryota
AlphaFoldDBP50461
Gene CardCSRP3
Uniprot IDP50461
PfamPF00412
In ASDno
Allosteric Predictionno (-0.703107877)
Ortholog in AnimalsAlpaca_ CSRP3 ( ortholog_one2one )
Dog_ CSRP3 ( ortholog_one2one )
GuineaPig_ CSRP3 ( ortholog_one2one )
Macaque_ CSRP3 ( ortholog_one2one )
Mouse_ Csrp3 ( ortholog_one2one )
Pig_ CSRP3 ( ortholog_one2one )
Rat_ Csrp3 ( ortholog_one2one )
Rabbit_ CSRP3 ( ortholog_one2one )
OhnologsCSRP2, CSRP1
ParalogsCSRP1, CSRP2
Tissueheart, atrium, left.ventricle
Tissue SpecificityCardiac and slow-twitch skeletal muscles. Isoform 2 is expressed in striated muscle. Isoform 2 is specifically expressed at higher levels in patients with neuromuscular diseases, such as limb-girdle muscular dystrophy 2A (LGMD2A), Duchenne muscular dystrophy (DMD) and dermatomyositis (PubMed:24860983). {ECO:0000269|PubMed:24860983}.
Pharmacological Animal ModelsNA
Gene Ontology
(biological process)
Gene Ontology
(cellular component)
Gene Ontology
(molecular function)
PDB 2O10  (NMR  -  )  2O13  (NMR  -  ) 
DBSNP rs45550635  rs104894205  rs281865416  rs104894204  rs45552933 
Subcellular location [CC]Nucleus {ECO:0000250|UniProtKB:P50463}. Cytoplasm {ECO:0000269|PubMed:18505755}. Cytoplasm, cytoskeleton {ECO:0000305}. Cytoplasm, myofibril, sarcomere, Z line {ECO:0000269|PubMed:24860983}. Cytoplasm, myofibril, sarcomere {ECO:0000269|PubMed:24934443}. Note=Nucleocytoplasmic shuttling protein. Mainly cytoplasmic. In the Z line, found associated with GLRX3 (By similarity). {ECO:0000250|UniProtKB:P50462, ECO:0000250|UniProtKB:P50463}.;
[Isoform 2]: Cytoplasm, myofibril, sarcomere, Z line {ECO:0000269|PubMed:24860983}.
Mouse PG classificationHPG
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