| Gene Information | |
|---|---|
| Gene Name | LRRC4C |
| Organism | Homo sapiens (Human) |
| Gene Length | 640 |
| Protein Names | Leucine-rich repeat-containing protein 4C (Netrin-G1 ligand) (NGL-1) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 680 ( ENSG00000148948 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | Q9HCJ2 |
| Gene Card | LRRC4C |
| Uniprot ID | Q9HCJ2 |
| Pfam | PF07679; PF13306; PF13855 |
| In ASD | no |
| Allosteric Prediction | no (-1.057413219) |
| Ortholog in Animals | Alpaca_ LRRC4C ( ortholog_one2one ) GuineaPig_ LRRC4C ( ortholog_one2one ) Macaque_ LRRC4C ( ortholog_one2one ) Mouse_ Lrrc4c ( ortholog_one2one ) Pig_ LRRC4C ( ortholog_one2one ) Rat_ Lrrc4c ( ortholog_one2one ) Rabbit_ LRRC4C ( ortholog_one2one ) |
| Ohnologs | LRRC4B, LRFN4, LRRC4, LRFN2 |
| Paralogs | LRTM1, LRRTM3, BGN, LRRTM1, LRRC19, RTN4RL2, LRRC4B, NYX, PODN, LRRC15, FLRT2, FLRT1, LRRTM4, LRRC66, RTN4RL1, LRRC4, ASPN, PODNL1, FLRT3, DCN, GP1BA, RTN4R |
| Tissue | brain, cerebral.cortex |
| Tissue Specificity | Highly expressed in the cerebral cortex, including frontal, parietal and occipital lobes. Putamen, amygdala, hippocampus and medulla oblongata show moderate expression. Caudate nucleus and thalamus express small amounts, whereas other brain regions show very weak or no expression. {ECO:0000269|PubMed:14595443}. |
| Pharmacological Animal Models | 0.000730(Chimpanzee);0.001000(Mouse);NULL(Rat);NULL(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 3ZYJ (X-ray 3.25A ) |
| DBSNP | NA |
| Subcellular location [CC] | Postsynaptic cell membrane {ECO:0000269|PubMed:14595443, ECO:0000269|PubMed:21946559}; Single-pass type I membrane protein {ECO:0000269|PubMed:14595443, ECO:0000269|PubMed:21946559}. |
| Mouse PG classification | NA |
| click here to return to the previous page | |